Plant Name: Euphorbia cattimandoo
Taxonomic Information:
Plant ID: NPO1814
Plant Latin Name: Euphorbia cattimandoo
Taxonomy Genus: Euphorbia
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
1129978
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GLI1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Unclassified | GLI1 | Zinc finger protein GLI1 | P08151 | CHEMBL5461 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032502; developmental process | GO:0060032; notochord regression | 1.035E-04 | 1.000E+00 | GLI1 |
| BP | GO:0032502; developmental process | GO:0007418; ventral midline development | 1.553E-04 | 1.000E+00 | GLI1 |
| BP | GO:0023052; signaling | GO:0021938; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation | 2.071E-04 | 1.000E+00 | GLI1 |
| BP | GO:0032502; developmental process | GO:0021696; cerebellar cortex morphogenesis | 2.589E-04 | 1.000E+00 | GLI1 |
| BP | GO:0032501; multicellular organismal process | GO:0048546; digestive tract morphogenesis | 8.283E-04 | 1.000E+00 | GLI1 |
| BP | GO:0032501; multicellular organismal process | GO:0009954; proximal/distal pattern formation | 1.346E-03 | 1.000E+00 | GLI1 |
| BP | GO:0032501; multicellular organismal process | GO:0021983; pituitary gland development | 1.398E-03 | 1.000E+00 | GLI1 |
| BP | GO:0008152; metabolic process | GO:0045740; positive regulation of DNA replication | 2.847E-03 | 1.000E+00 | GLI1 |
| BP | GO:0032501; multicellular organismal process | GO:0030324; lung development | 3.935E-03 | 1.000E+00 | GLI1 |
| BP | GO:0050896; response to stimulus | GO:0009611; response to wounding | 9.267E-03 | 1.000E+00 | GLI1 |
| MF | GO:0140110; transcription regulator activity | GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | 5.125E-03 | 1.000E+00 | GLI1 |
| MF | GO:0005488; binding | GO:0000978; RNA polymerase II proximal promoter sequence-specific DNA binding | 2.040E-02 | 1.000E+00 | GLI1 |
| MF | GO:0005488; binding | GO:0003682; chromatin binding | 2.594E-02 | 1.000E+00 | GLI1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05217 | Basal cell carcinoma | 2.750E-03 | 5.500E-03 | GLI1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04340 | Hedgehog signaling pathway | 2.500E-03 | 5.500E-03 | GLI1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 9.950E-03 | 1.327E-02 | GLI1 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.985E-02 | 1.985E-02 | GLI1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
