Plant Name: Cicuta virosa
Taxonomic Information:
Plant ID: NPO18101
Plant Latin Name: Cicuta virosa
Taxonomy Genus: Cicuta
Taxonomy Family: Apiaceae
Plant External Links:
NCBI TaxonomyDB:
48109
Plant-of-the-World-Online:
840414-1
Used in Medicines:
Country/Region:
China; Finland; IndiaTraditional Medicine System:
Indian Folk; TCM; HomeopathyMedicinal Functions:
Analgesic; Antispasmodic; Emetic; Galactofuge; Sedative
Geographical Distribution:
Canada; Turkey; Italy; Mongolia; France; Ireland; Norway; Belarus; China; Belgium; Germany; Kazakhstan; Ukraine; Netherlands; Denmark; Poland; Finland; United States; Sweden; Japan; Switzerland; Russia; Bulgaria; Romania; South Africa; India; United Kingdom; Austria; Greece; Hungary
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| OPRK1; | |
| ACHE; | |
| SMN1;SMN2; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Peptide receptor (family A GPCR) | OPRK1 | Kappa opioid receptor | P41145 | CHEMBL237 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0031635; adenylate cyclase-inhibiting opioid receptor signaling pathway | 4.141E-04 | 9.018E-01 | OPRK1 |
| MF | GO:0003824; catalytic activity | GO:0003990; acetylcholinesterase activity | 4.141E-04 | 9.018E-01 | ACHE |
| BP | GO:0007610; behavior | GO:0007612; learning | 2.787E-02 | 1.000E+00 | OPRK1 |
| CC | GO:0044456; synapse part | GO:0043679; axon terminus | 1.134E-02 | 1.000E+00 | OPRK1 |
| CC | GO:0044464; cell part | GO:0043204; perikaryon | 2.360E-02 | 1.000E+00 | OPRK1 |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 3.333E-02 | 1.000E+00 | LMNA |
| MF | GO:0005488; binding | GO:0042923; neuropeptide binding | 4.548E-03 | 1.000E+00 | OPRK1 |
| MF | GO:0005488; binding | GO:0043621; protein self-association | 1.114E-02 | 1.000E+00 | ACHE |
| MF | GO:0003824; catalytic activity | GO:0052689; carboxylic ester hydrolase activity | 2.909E-02 | 1.000E+00 | ACHE |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.472E-02 | 3.082E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.650E-02 | 3.082E-02 | LMNA |
| 09150 Organismal Systems | 09156 Nervous system | hsa04725 | Cholinergic synapse | 2.202E-02 | 3.082E-02 | ACHE |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.788E-02 | 3.082E-02 | LMNA |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.771E-02 | 3.233E-02 | LMNA |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00564 | Glycerophospholipid metabolism | 1.887E-02 | 3.082E-02 | ACHE |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 5.426E-02 | 5.426E-02 | OPRK1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
