Plant Name: Senecio macrocephalus
Taxonomic Information:
Plant ID: NPO1807
Plant Latin Name: Senecio macrocephalus
Taxonomy Genus: Senecio
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0055015; ventricular cardiac muscle cell development | 1.552E-03 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0071404; cellular response to low-density lipoprotein particle stimulus | 2.173E-03 | 1.000E+00 | NPC1 |
| BP | Unclassified; | GO:2000188; regulation of cholesterol homeostasis | 2.173E-03 | 1.000E+00 | NPC1 |
| BP | GO:0009987; cellular process | GO:0090201; negative regulation of release of cytochrome c from mitochondria | 2.638E-03 | 1.000E+00 | LMNA |
| BP | GO:0051179; localization | GO:0033344; cholesterol efflux | 3.723E-03 | 1.000E+00 | NPC1 |
| BP | GO:0007610; behavior | GO:0007628; adult walking behavior | 4.188E-03 | 1.000E+00 | NPC1 |
| BP | GO:0009987; cellular process | GO:0007077; mitotic nuclear envelope disassembly | 6.819E-03 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0060548; negative regulation of cell death | 7.070E-03 | 1.000E+00 | LMNA, NPC1 |
| BP | GO:0051179; localization | GO:0032880; regulation of protein localization | 8.236E-03 | 1.000E+00 | LMNA, RAB9A |
| BP | GO:0050896; response to stimulus | GO:0046686; response to cadmium ion | 8.673E-03 | 1.000E+00 | NPC1 |
| BP | GO:0065007; biological regulation | GO:0042632; cholesterol homeostasis | 1.022E-02 | 1.000E+00 | NPC1 |
| BP | GO:0009987; cellular process | GO:0071383; cellular response to steroid hormone stimulus | 1.145E-02 | 1.000E+00 | NPC1 |
| BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 1.591E-02 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.607E-02 | 1.000E+00 | LMNA |
| BP | GO:0051179; localization | GO:1900180; regulation of protein localization to nucleus | 3.393E-02 | 1.000E+00 | LMNA |
| BP | GO:0008152; metabolic process | GO:0006486; protein glycosylation | 4.271E-02 | 1.000E+00 | NPC1 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 5.958E-04 | 1.000E+00 | NPC1, RAB9A |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 1.561E-02 | 1.000E+00 | RAB9A |
| CC | GO:0016020; membrane | GO:0045121; membrane raft | 4.482E-02 | 1.000E+00 | NPC1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.106E-02 | 2.085E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.240E-02 | 2.085E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.344E-02 | 2.085E-02 | LMNA |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.085E-02 | 2.085E-02 | LMNA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 2.026E-02 | 2.085E-02 | RAB9A |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 1.834E-02 | 2.085E-02 | NPC1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
