CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	PTGES; ALOX15;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Oxidoreductase	MAOA;
Transcription Factor	TP53;
Unclassified	FABP3; LMNA; FABP4; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	PTGES	Prostaglandin E synthase	O14684	CHEMBL5658
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339

Showing 1 to 10 of 15 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	8.625E-07	3.130E-03	FABP3, FABP4, FABP5
BP	GO:0050896; response to stimulus	GO:0010038; response to metal ion	3.121E-06	6.178E-03	ALOX15, FABP4, MAPK1, PTGES, TP53
BP	GO:0050896; response to stimulus	GO:1901652; response to peptide	4.842E-06	8.785E-03	FABP3, FFAR4, PPARA, TP53, TSHR
MF	GO:0005488; binding	GO:0005504; fatty acid binding	4.088E-09	8.902E-05	FABP3, FABP4, FABP5, FFAR4

Showing 1 to 4 of 4 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.673E-04	9.555E-03	ALOX15, PTGES
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	4.042E-04	7.680E-03	MAPK1, PPARA, TSHR
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.436E-04	4.560E-03	LMNA, MAPK1, TP53
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.721E-07	2.185E-05	FABP3, FABP4, FABP5, PPARA
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	7.406E-05	4.560E-03	MAOA, ALOX15, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7.898E-04	9.555E-03	FABP4, TSHR
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.234E-04	4.560E-03	MAPK1, PPARA, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.107E-04	5.351E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	4.233E-04	7.680E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	6.813E-04	9.555E-03	MAPK1, TP53

Showing 1 to 10 of 17 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;

Showing 1 to 10 of 35 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Curcuma phaeocaulis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities