Plant Name: Helenium arizonicum
Taxonomic Information:
Plant ID: NPO17965
Plant Latin Name: Helenium arizonicum
Taxonomy Genus: Helenium
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
373174
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TRPA1; | |
| P4HB; AKR1B1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | P4HB | Protein disulfide-isomerase | P07237 | CHEMBL5422 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0042542; response to hydrogen peroxide | 9.258E-05 | 4.227E-01 | AKR1B1, TRPA1 |
| BP | GO:0050896; response to stimulus | GO:0009628; response to abiotic stimulus | 1.409E-04 | 4.227E-01 | AKR1B1, P4HB, TRPA1 |
| BP | GO:0009987; cellular process | GO:0034599; cellular response to oxidative stress | 2.991E-04 | 4.227E-01 | AKR1B1, P4HB |
| CC | GO:0044464; cell part | GO:0032421; stereocilium bundle | 7.764E-04 | 6.262E-01 | TRPA1 |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 1.037E-02 | 1.000E+00 | AKR1B1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 5.391E-03 | 1.258E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 4.493E-03 | 1.258E-02 | AKR1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 8.824E-03 | 1.544E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 4.793E-03 | 1.258E-02 | AKR1B1 |
| 09150 Organismal Systems | 09157 Sensory system | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.463E-02 | 2.048E-02 | TRPA1 |
| 09120 Genetic Information Processing | 09123 Folding, sorting and degradation | hsa04141 | Protein processing in endoplasmic reticulum | 2.514E-02 | 2.933E-02 | P4HB |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.746E-01 | 1.746E-01 | AKR1B1 |
Human Diseases Associated with the Target Proteins of the Plant
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
