Plant Name: Aconitum kusnezoffii reichb
Taxonomic Information:
Plant ID: NPO17871
Plant Latin Name: Aconitum kusnezoffii reichb
Taxonomy Genus: Aconitum
Taxonomy Family: Ranunculaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| PPARD; PPARA; | |
| TLR2; | |
| FABP3; FABP4; LMNA; FABP5; FABP2; | |
| POLB; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2D6; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 7.155E-10 | 5.194E-06 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 6.452E-06 | 7.805E-03 | FABP3, PPARA, PPARD |
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 9.679E-06 | 1.054E-02 | LMNA, PPARA, PPARD, TLR2 |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 1.617E-05 | 1.427E-02 | PPARA, PPARD |
| BP | GO:0008152; metabolic process | GO:0006631; fatty acid metabolic process | 1.638E-05 | 1.427E-02 | CYP2D6, FABP3, PPARA, PPARD |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 1.617E-05 | 1.427E-02 | FABP3, PPARD |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 6.152E-13 | 2.522E-11 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 4.167E-04 | 8.543E-03 | FABP4, TSHR |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 5.107E-03 | 6.980E-02 | PPARA, TSHR |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.801E-02 | 9.827E-02 | POLB |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 2.877E-02 | 9.827E-02 | TSHR |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 2.984E-02 | 9.827E-02 | TLR2 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 3.518E-02 | 9.827E-02 | TLR2 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 3.731E-02 | 9.827E-02 | CYP2D6 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 3.837E-02 | 9.827E-02 | TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 3.784E-02 | 9.827E-02 | PPARA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR; |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR; |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR; |
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>> Targets derived from weak experimental activities
