CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	RECQL;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Showing 1 to 3 of 3 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0048699; generation of neurons	1.242E-03	1.000E+00	MAPT
BP	GO:0009987; cellular process	GO:1990000; amyloid fibril formation	1.242E-03	1.000E+00	MAPT
BP	GO:0009987; cellular process	GO:0019896; axonal transport of mitochondrion	1.397E-03	1.000E+00	MAPT
BP	GO:0032501; multicellular organismal process	GO:0048143; astrocyte activation	1.397E-03	1.000E+00	MAPT
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	1.397E-03	1.000E+00	RECQL
BP	GO:0008152; metabolic process	GO:0032930; positive regulation of superoxide anion generation	2.173E-03	1.000E+00	MAPT
BP	GO:0002376; immune system process	GO:0001774; microglial cell activation	2.638E-03	1.000E+00	MAPT
BP	GO:0009987; cellular process	GO:1901216; positive regulation of neuron death	1.191E-02	1.000E+00	MAPT
BP	GO:0009987; cellular process	GO:1900034; regulation of cellular response to heat	1.207E-02	1.000E+00	MAPT
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	1.268E-02	1.000E+00	MAPT

Showing 1 to 10 of 25 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	3.777E-02	3.777E-02	MAPT
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	2.499E-02	3.777E-02	MAPT

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Onosma paniculata

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities