CMAUP Plant Collective Molecular Activities

Plant Name: Ibervillea sonorae

Taxonomic Information:

Plant ID: NPO17829
Plant Latin Name: Ibervillea sonorae
Taxonomy Genus: Ibervillea
Taxonomy Family: Cucurbitaceae

Plant External Links:

NCBI TaxonomyDB: 354617
Plant-of-the-World-Online: 127278-2

Used in Medicines:

Country/Region:

Mexico

Traditional Medicine System:

Geographical Distribution:

Mexico

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	PIM1; AURKB; AURKA; KDR;
Enzyme_unclassified	GFER;
Unclassified	RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.245E-06	2.099E-02	AURKA, AURKB, KDR, PIM1
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	1.928E-06	2.099E-02	AURKA, AURKB
MF	GO:0003824; catalytic activity	GO:0035174; histone serine kinase activity	2.892E-06	2.099E-02	AURKA, AURKB
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.667E-06	3.909E-02	CYP1A1, CYP1B1
BP	GO:0008152; metabolic process	GO:0035404; histone-serine phosphorylation	1.271E-05	3.909E-02	AURKA, AURKB
CC	GO:0043226; organelle	GO:0000780; condensed nuclear chromosome, centromeric region	1.271E-05	3.909E-02	AURKA, AURKB
CC	GO:0043226; organelle	GO:0031616; spindle pole centrosome	1.271E-05	3.909E-02	AURKA, AURKB
BP	GO:0009987; cellular process	GO:0060548; negative regulation of cell death	3.102E-05	5.254E-02	AURKA, AURKB, KDR, NPC1, PIM1
MF	GO:0005488; binding	GO:0008144; drug binding	3.378E-05	5.254E-02	AURKA, AURKB, CYP1A1, CYP1B1, KDR, PIM1
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	3.700E-05	5.371E-02	CYP1A1, CYP1B1, KDR, NPC1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.034E-05	5.490E-02	CYP1A1, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.858E-05	5.877E-02	CYP1A1, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.858E-05	5.877E-02	CYP1A1, CYP1B1
BP	GO:0008152; metabolic process	GO:1903409; reactive oxygen species biosynthetic process	5.298E-05	6.072E-02	CYP1A1, CYP1B1
CC	GO:0043226; organelle	GO:0051233; spindle midzone	8.911E-05	8.436E-02	AURKA, AURKB
MF	GO:0005488; binding	GO:0000166; nucleotide binding	1.035E-04	9.038E-02	AURKA, AURKB, GFER, KDR, PIM1, RAB9A
CC	GO:0043226; organelle	GO:0005876; spindle microtubule	2.627E-04	1.631E-01	AURKA, AURKB
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	2.870E-04	1.631E-01	AURKA, AURKB, CYP1A1, CYP1B1, GFER, KDR, NPC1, PIM1, RAB9A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.392E-04	2.154E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.181E-04	2.154E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.937E-04	2.154E-03	CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.653E-04	2.559E-03	CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.867E-04	2.582E-03	CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	7.385E-03	2.708E-02	PIM1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.536E-02	7.059E-02	PIM1
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	2.712E-02	7.059E-02	KDR
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4.455E-02	9.801E-02	PIM1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.888E-02	7.059E-02	CYP1A1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	AURKA; KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	AML	NA	KDR;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKA; AURKB;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	Breast cancer	C50	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Liver cancer	C22	KDR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	AURKA; AURKB; KDR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	KDR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases