Plant Name: Scutellaria przewalskii
Taxonomic Information:
Plant ID: NPO17827
Plant Latin Name: Scutellaria przewalskii
Taxonomy Genus: Scutellaria
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0071404; cellular response to low-density lipoprotein particle stimulus | 2.896E-03 | 1.000E+00 | NPC1 |
| BP | Unclassified; | GO:2000188; regulation of cholesterol homeostasis | 2.896E-03 | 1.000E+00 | NPC1 |
| BP | GO:0051179; localization | GO:0033344; cholesterol efflux | 4.961E-03 | 1.000E+00 | NPC1 |
| BP | GO:0007610; behavior | GO:0007628; adult walking behavior | 5.580E-03 | 1.000E+00 | NPC1 |
| BP | GO:0050896; response to stimulus | GO:0046686; response to cadmium ion | 1.155E-02 | 1.000E+00 | NPC1 |
| BP | GO:0065007; biological regulation | GO:0042632; cholesterol homeostasis | 1.360E-02 | 1.000E+00 | NPC1 |
| BP | GO:0009987; cellular process | GO:0060548; negative regulation of cell death | 1.368E-02 | 1.000E+00 | NPC1, PIM1 |
| BP | GO:0009987; cellular process | GO:0071383; cellular response to steroid hormone stimulus | 1.524E-02 | 1.000E+00 | NPC1 |
| BP | GO:0032501; multicellular organismal process | GO:0001889; liver development | 2.157E-02 | 1.000E+00 | GFER |
| BP | GO:0065007; biological regulation | GO:0043433; negative regulation of DNA binding transcription factor activity | 2.888E-02 | 1.000E+00 | PIM1 |
| BP | GO:0008152; metabolic process | GO:0046777; protein autophosphorylation | 3.998E-02 | 1.000E+00 | PIM1 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 1.180E-03 | 1.000E+00 | NPC1, RAB9A |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 2.075E-02 | 1.000E+00 | RAB9A |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 3.333E-02 | 1.000E+00 | NPC1 |
| MF | GO:0005488; binding | GO:0050660; flavin adenine dinucleotide binding | 1.524E-02 | 1.000E+00 | GFER |
| MF | GO:0005488; binding | GO:0035639; purine ribonucleoside triphosphate binding | 4.646E-02 | 1.000E+00 | PIM1, RAB9A |
| MF | GO:0005488; binding | GO:0032555; purine ribonucleotide binding | 4.854E-02 | 1.000E+00 | PIM1, RAB9A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.135E-02 | 3.748E-02 | PIM1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2.005E-02 | 3.748E-02 | PIM1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 2.693E-02 | 3.748E-02 | RAB9A |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 2.438E-02 | 3.748E-02 | NPC1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 3.123E-02 | 3.748E-02 | PIM1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 5.809E-02 | 5.809E-02 | PIM1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
