CMAUP Plant Collective Molecular Activities

Plant Name: Dysosma versipellis

Taxonomic Information:

Plant ID: NPO17807
Plant Latin Name: Dysosma versipellis
Taxonomy Genus: Dysosma
Taxonomy Family: Berberidaceae

Plant External Links:

NCBI TaxonomyDB: 93611
Plant-of-the-World-Online: 107257-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Serine protease	ELANE;
Toll-like and Il-1 receptors	TLR2;
Unclassified	MAPT; HTT; FABP3; LMNA; FABP2; FABP4; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Serine protease	ELANE	Leukocyte elastase	P08246	CHEMBL248
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.900E-08	1.034E-04	FABP2, FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.942E-08	1.280E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.222E-07	6.852E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	3.461E-07	6.852E-04	CYP2C19, CYP2C9, CYP3A4, NPC1, NR0B1, PPARD
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	6.656E-07	1.115E-03	NR0B1, NR3C1, PPARA, PPARD
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	7.151E-06	6.253E-03	HIF1A, MAPT, NR3C1
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	8.126E-06	6.253E-03	CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	8.614E-06	6.253E-03	CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	1.152E-05	7.836E-03	HIF1A, LMNA, PPARA, PPARD, TLR2
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	1.571E-05	9.500E-03	NR0B1, NR3C1, PPARA, PPARD
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.025E-05	1.161E-02	CYP2C19, CYP2C9, CYP3A4
CC	GO:0044464; cell part	GO:0005737; cytoplasm	4.961E-05	1.959E-02	CYP3A4, ELANE, FABP3, FABP4, FABP5, HIF1A, HTT, MAPT, NPSR1, NR0B1, NR3C1, SMN1, SMN2, TLR2
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	8.887E-05	2.481E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	1.049E-04	2.753E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	2.051E-04	4.379E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.301E-10	7.677E-09	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.760E-06	1.404E-04	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.624E-05	1.303E-03	CYP2C9, CYP3A4, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.109E-04	1.635E-03	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.294E-03	2.476E-02	CYP2C9, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.518E-03	2.476E-02	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.164E-03	2.666E-02	CYP2C9, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.024E-02	6.240E-02	PAX8, HIF1A, PPARD
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	7.282E-03	5.371E-02	CYP2C9, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	1.058E-02	6.240E-02	RAB9A, TLR2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases