CMAUP Plant Collective Molecular Activities

Plant Name: Richteria pyrethroides

Taxonomic Information:

Plant ID: NPO17806
Plant Latin Name: Richteria pyrethroides
Taxonomy Genus: Richteria
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 457731
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; RECQL; HPGD; ALDH1A1;
Hydrolase	GAA;
Nuclear hormone receptor subfamily 1 group A	THRB;
Unclassified	RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0000023; maltose metabolic process	1.087E-03	1.000E+00	GAA
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	2.173E-03	1.000E+00	HPGD
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	3.257E-03	1.000E+00	RECQL
BP	GO:0032501; multicellular organismal process	GO:0050884; neuromuscular process controlling posture	3.980E-03	1.000E+00	GAA
BP	GO:0008152; metabolic process	GO:0006069; ethanol oxidation	4.341E-03	1.000E+00	ALDH1A1
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	5.785E-03	1.000E+00	HPGD
BP	GO:0009987; cellular process	GO:0046716; muscle cell cellular homeostasis	6.506E-03	1.000E+00	GAA
BP	GO:0022414; reproductive process	GO:0030728; ovulation	6.506E-03	1.000E+00	HPGD
BP	GO:0008283; cell proliferation	GO:1904707; positive regulation of vascular smooth muscle cell proliferation	7.947E-03	1.000E+00	HPGD
BP	GO:0008152; metabolic process	GO:0006693; prostaglandin metabolic process	9.386E-03	1.000E+00	HPGD
BP	GO:0008152; metabolic process	GO:0042572; retinol metabolic process	1.082E-02	1.000E+00	ALDH1A1
BP	GO:0032501; multicellular organismal process	GO:0003007; heart morphogenesis	1.154E-02	1.000E+00	GAA
BP	GO:0008152; metabolic process	GO:0006006; glucose metabolic process	3.989E-02	1.000E+00	GAA
BP	GO:0050896; response to stimulus	GO:0045471; response to ethanol	4.129E-02	1.000E+00	HPGD
BP	GO:0050896; response to stimulus	GO:0032355; response to estradiol	4.409E-02	1.000E+00	HPGD
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	4.618E-02	1.000E+00	THRB
CC	GO:0044421; extracellular region part	GO:0070062; extracellular exosome	1.054E-03	1.000E+00	ALDH1A1, GAA, HPGD, RAB9A, THRB
CC	GO:0043226; organelle	GO:0042470; melanosome	3.604E-02	1.000E+00	RAB9A
CC	GO:0044464; cell part	GO:0005770; late endosome	4.792E-02	1.000E+00	RAB9A
MF	GO:0003824; catalytic activity	GO:0004574; oligo-1,6-glucosidase activity	7.247E-04	1.000E+00	GAA
MF	GO:0003824; catalytic activity	GO:0032450; maltose alpha-glucosidase activity	1.087E-03	1.000E+00	GAA
MF	GO:0005488; binding	GO:0005497; androgen binding	1.449E-03	1.000E+00	ALDH1A1
MF	GO:0003824; catalytic activity	GO:0004558; alpha-1,4-glucosidase activity	1.449E-03	1.000E+00	GAA
MF	GO:0003824; catalytic activity	GO:0009378; four-way junction helicase activity	1.811E-03	1.000E+00	RECQL
MF	GO:0003824; catalytic activity	GO:0043140; ATP-dependent 3'-5' DNA helicase activity	2.534E-03	1.000E+00	RECQL
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	2.534E-03	1.000E+00	ALDH1A1
MF	GO:0005488; binding	GO:0070324; thyroid hormone binding	2.534E-03	1.000E+00	THRB
MF	GO:0060089; molecular transducer activity	GO:0004887; thyroid hormone receptor activity	2.534E-03	1.000E+00	THRB
MF	GO:0005488; binding	GO:0036310; annealing helicase activity	2.896E-03	1.000E+00	RECQL
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	2.119E-02	1.000E+00	THRB

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1.944E-02	6.760E-02	GAA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.045E-02	6.760E-02	GAA
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.253E-02	6.760E-02	ALDH1A1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	4.058E-02	6.997E-02	THRB
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	4.665E-02	6.997E-02	RAB9A
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	4.227E-02	6.997E-02	GAA
Unclassified	Unclassified	hsa01100	Metabolic pathways	6.539E-02	7.357E-02	GAA, ALDH1A1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	6.133E-02	7.357E-02	HPGD
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9.303E-02	9.303E-02	THRB

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB;
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases