CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD1;
Enzyme_unclassified	MTOR;
Transcription Factor	TP53;
SLC superfamily of solute carriers	SLC10A1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	THPO; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP1A2; CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
SLC superfamily of solute carriers	SLC10A1	Bile acid transporter	Q14973	CHEMBL5287
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.745E-09	5.978E-05	CYP1A2, CYP2C19, CYP2D6
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	6.182E-06	3.365E-02	CYP1A2, CYP2D6
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.940E-05	3.382E-02	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.940E-05	3.382E-02	CYP1A2, CYP2D6
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	1.940E-05	3.382E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	2.292E-05	3.382E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	4.489E-05	4.093E-02	SMN1, SMN2
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.924E-06	2.095E-02	CYP1A2, CYP2C19, CYP2D6
MF	GO:0003824; catalytic activity	GO:0004497; monooxygenase activity	1.848E-05	3.382E-02	CYP1A2, CYP2C19, CYP2D6
MF	GO:0005488; binding	GO:0020037; heme binding	4.511E-05	4.093E-02	CYP1A2, CYP2C19, CYP2D6

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.357E-06	4.895E-04	CYP2D6, CYP1A2, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.108E-04	4.264E-03	CYP1A2, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.075E-04	1.090E-02	CYP2D6, CYP1A2
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.169E-03	1.126E-02	TP53, MTOR
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.654E-03	1.412E-02	CYP2D6, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.833E-03	1.412E-02	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	5.613E-04	1.090E-02	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	5.963E-04	1.090E-02	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.049E-03	1.126E-02	TP53, MTOR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	8.917E-04	1.126E-02	CYP1A2, CYP2C19

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Lamprocapnos spectabilis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities