CMAUP Plant Collective Molecular Activities

Plant Name: Curcuma heyneana

Taxonomic Information:

Plant ID: NPO17780
Plant Latin Name: Curcuma heyneana
Taxonomy Genus: Curcuma
Taxonomy Family: Zingiberaceae

Plant External Links:

NCBI TaxonomyDB: 378295
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Indonesia

Traditional Medicine System:

Geographical Distribution:

Indonesia

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN2;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	6.074E-06	3.805E-02	SLCO1B1, SLCO1B3
BP	GO:0051179; localization	GO:0015721; bile acid and bile salt transport	6.989E-06	3.805E-02	SLCO1B1, SLCO1B3
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	2.459E-06	3.805E-02	SLCO1B1, SLCO1B3
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	4.435E-06	3.805E-02	SLCO1B1, SLCO1B3
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.749E-04	3.074E-01	SLCO1B1, SLCO1B3
CC	GO:0016020; membrane	GO:0005886; plasma membrane	1.183E-02	1.000E+00	PTPN2, SLCO1B1, SLCO1B3
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	1.518E-02	1.000E+00	SLCO1B1, SLCO1B3

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.719E-05	7.438E-05	SLCO1B1, SLCO1B3
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	2.351E-02	2.351E-02	PTPN2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases