Plant Name: Artocarpus heterophyllus
Taxonomic Information:
Plant ID: NPO17767
Plant Latin Name: Artocarpus heterophyllus
Taxonomy Genus: Artocarpus
Taxonomy Family: Moraceae
Plant External Links:
NCBI TaxonomyDB:
3489
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Thailand; IndonesiaTraditional Medicine System:
Geographical Distribution:
Thailand; Indonesia
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ADORA3; | |
| RXRA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP19A1; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Nuclear hormone receptor subfamily 2 group B | RXRA | Retinoid X receptor alpha | P19793 | CHEMBL2061 |
| Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016125; sterol metabolic process | 1.301E-04 | 8.898E-01 | CYP19A1, RXRA |
| BP | GO:0040011; locomotion | GO:0030336; negative regulation of cell migration | 5.574E-04 | 8.898E-01 | ADORA3, CYP19A1 |
| BP | GO:0008152; metabolic process | GO:0061370; testosterone biosynthetic process | 7.764E-04 | 8.898E-01 | CYP19A1 |
| MF | GO:0005488; binding | GO:0050692; DBD domain binding | 4.659E-04 | 8.898E-01 | RXRA |
| MF | GO:0005488; binding | GO:0050693; LBD domain binding | 9.316E-04 | 9.660E-01 | RXRA |
| MF | GO:0060089; molecular transducer activity | GO:0001609; G-protein coupled adenosine receptor activity | 1.087E-03 | 9.861E-01 | ADORA3 |
| CC | GO:0032991; macromolecular complex | GO:0090575; RNA polymerase II transcription factor complex | 2.021E-02 | 1.000E+00 | RXRA |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 4.918E-02 | 1.000E+00 | RXRA |
| MF | GO:0005488; binding | GO:0046914; transition metal ion binding | 8.875E-03 | 1.000E+00 | CYP19A1, RXRA |
| MF | Unclassified; | GO:0004871; signal transducer activity | 2.224E-02 | 1.000E+00 | ADORA3, RXRA |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 4.344E-03 | 2.729E-02 | RXRA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 7.482E-03 | 2.729E-02 | CYP19A1 |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 8.377E-03 | 2.729E-02 | RXRA |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 8.675E-03 | 2.729E-02 | CYP19A1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 1.046E-02 | 2.729E-02 | RXRA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.031E-02 | 2.729E-02 | RXRA |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 1.285E-02 | 2.890E-02 | RXRA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 2.729E-02 | RXRA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.760E-02 | 3.221E-02 | RXRA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 1.789E-02 | 3.221E-02 | ADORA3 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cutaneous T-cell lymphoma | C84.0, C84.1 | RXRA; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
