CMAUP Plant Collective Molecular Activities

Plant Name: Helichrysum cymosum

Taxonomic Information:

Plant ID: NPO17726
Plant Latin Name: Helichrysum cymosum
Taxonomy Genus: Helichrysum
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 379243
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Africa

Traditional Medicine System:

Geographical Distribution:

South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	AMY1A;AMY1B;AMY1C; TDP1; HPGD; AKR1B1; ALDH1A1;
Lyase	CA2; CA1; CA12; CA9; CA5B; CA3; CA14; CA7; CA5A; CA4; CA6;
Lysine demethylase	KDM4E;
Serine protease	F10;
Aspartic protease	BACE1;
Transferase	FUT7;
Unclassified	LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Enzyme_unclassified	AMY1A;AMY1B;AMY1C	Salivary alpha-amylase	P04745	CHEMBL2478
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Serine protease	F10	Coagulation factor X	P00742	CHEMBL244
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004556; alpha-amylase activity	1.683E-08	3.053E-05	AMY1A, AMY1B, AMY1C
MF	Unclassified;	GO:0103025; alpha-amylase activity (releasing maltohexaose)	1.683E-08	3.053E-05	AMY1A, AMY1B, AMY1C
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.893E-08	3.171E-05	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.742E-31	2.121E-26	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	4.829E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.376E-24	5.853E-20	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.465E-22	1.342E-18	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0005975; carbohydrate metabolic process	1.733E-05	1.716E-02	AKR1B1, ALDH1A1, AMY1A, AMY1B, AMY1C, FUT7
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.213E-05	2.095E-02	CA1, CA2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.016E-30	1.504E-28	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4.036E-05	3.364E-04	AMY1A, AMY1B, AMY1C
09150 Organismal Systems	09154 Digestive system	hsa04973	Carbohydrate digestion and absorption	2.084E-05	2.605E-04	AMY1A, AMY1B, AMY1C
09150 Organismal Systems	09154 Digestive system	hsa04970	Salivary secretion	1.611E-04	1.007E-03	AMY1A, AMY1B, AMY1C
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.859E-03	1.191E-02	FUT7, AMY1A, AMY1B, AMY1C, ALDH1A1, AKR1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.438E-04	1.719E-03	CA2, CA4
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.715E-02	6.125E-02	BACE1, MAPT
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	3.541E-02	7.859E-02	AKR1B1
09100 Metabolism	09107 Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3.657E-02	7.859E-02	FUT7
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3.772E-02	7.859E-02	AKR1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Deep vein thrombosis	I80-I82, I80.2	F10;
C00-D49: Neoplasms	Renal cancer	C64	F10;
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	F10;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Thromboembolic disorders	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Coagulation	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Prophylaxis of deep vein thrombosis	I80-I82, I80.2	F10;
NA: NA	Christmas disease	NA	F10;
I00-I99: Diseases of the circulatory system	Venous thrombosis	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Venous thromboembolism	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	F10;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Blood coagulation disorders	D65-D68	F10;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F10;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	F10;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	F10;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	F10;
I00-I99: Diseases of the circulatory system	Deep venous clots	I80.2	F10;
NA: NA	Haemophilia B	NA	F10;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hematology	D50-D77	F10;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hemophilia	D66-D68	F10;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases