CMAUP Plant Collective Molecular Activities

Plant Name: Oenothera odorata

Taxonomic Information:

Plant ID: NPO17721
Plant Latin Name: Oenothera odorata
Taxonomy Genus: Oenothera
Taxonomy Family: Onagraceae

Plant External Links:

NCBI TaxonomyDB: 3951
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Geographical Distribution:

India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Oxidoreductase	ALOX5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0032787; monocarboxylic acid metabolic process	2.480E-02	1.000E+00	ALOX5
BP	GO:0002376; immune system process	GO:0043312; neutrophil degranulation	2.495E-02	1.000E+00	ALOX5
BP	GO:0002376; immune system process	GO:0045321; leukocyte activation	4.364E-02	1.000E+00	ALOX5
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	4.649E-02	1.000E+00	ALOX5
BP	GO:0009987; cellular process	GO:0032940; secretion by cell	4.861E-02	1.000E+00	ALOX5
CC	GO:0044464; cell part	GO:0005641; nuclear envelope lumen	4.142E-04	1.000E+00	ALOX5
CC	GO:0044464; cell part	GO:0034774; secretory granule lumen	1.662E-02	1.000E+00	ALOX5
MF	GO:0005488; binding	GO:0005506; iron ion binding	8.283E-03	1.000E+00	ALOX5

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.500E-03	7.375E-03	ALOX5
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.100E-03	7.375E-03	ALOX5
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	5.600E-03	7.375E-03	ALOX5
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	5.900E-03	7.375E-03	ALOX5
Unclassified	Unclassified	hsa01100	Metabolic pathways	6.195E-02	6.195E-02	ALOX5

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5;
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases