CMAUP Plant Collective Molecular Activities

Plant Name: Andira inermis

Taxonomic Information:

Plant ID: NPO17675
Plant Latin Name: Andira inermis
Taxonomy Genus: Andira
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 53825
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Brazil; China

Traditional Medicine System:

TCM

Geographical Distribution:

Brazil; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	BLM; AOX1;
Protein Kinase	EGFR;
Lyase	CA7; CA4; CA12;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group B	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.015E-08	1.106E-04	BLM, CA12, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.078E-07	3.355E-04	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0005496; steroid binding	2.540E-07	6.912E-04	ESR1, ESR2, ESRRA, ESRRB
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	4.181E-07	1.012E-03	ESR1, ESR2
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	1.336E-06	2.910E-03	ESR1, ESR2, ESRRA, ESRRB
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.679E-06	3.323E-03	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	2.507E-06	4.101E-03	ESR1, ESR2
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	3.059E-06	4.224E-03	ESR1, ESR2, ESRRA, ESRRB
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.104E-06	4.224E-03	CA12, CA4, CA7
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	4.367E-06	5.283E-03	ESR1, ESR2, ESRRA, ESRRB
MF	GO:0098772; molecular function regulator	GO:0030235; nitric-oxide synthase regulator activity	8.764E-06	9.088E-03	EGFR, ESR1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.451E-07	8.997E-06	CA12, CA4, CA7
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	3.246E-05	1.006E-03	ESR1, EGFR, ESR2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases