CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA2; CA12; CA1; CA9;
Nuclear hormone receptor subfamily 3 group C	AR;
Enzyme_unclassified	ALOX15; HPGD; PARP1; TNKS2; TNKS;
Transcription Factor	TP53;
Unclassified	MAPT; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A1; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	PARP1	Poly [ADP-ribose] polymerase-1	P09874	CHEMBL3105
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.376E-08	7.392E-05	CA1, CA12, CA2, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.453E-08	1.484E-04	CA1, CA12, CA2, CA9
BP	GO:0065007; biological regulation	GO:1904357; negative regulation of telomere maintenance via telomere lengthening	1.635E-06	1.695E-03	PARP1, TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	4.370E-06	3.172E-03	TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.370E-06	3.172E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0070212; protein poly-ADP-ribosylation	1.091E-05	6.254E-03	PARP1, TNKS
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	1.091E-05	6.254E-03	ALOX15, HPGD
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.035E-05	9.847E-03	CYP1A1, CYP1A2
CC	GO:0016020; membrane	GO:0016020; membrane	6.198E-05	2.142E-02	ALOX15, AR, CA12, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, HPGD, MAPT, NPC1, PARP1, RAB9A, TNKS, TNKS2
CC	GO:0043226; organelle	GO:0000242; pericentriolar material	1.372E-04	3.557E-02	TNKS, TNKS2

Showing 1 to 10 of 18 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.442E-10	4.981E-08	CA12, CA1, CA2, CA9
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.529E-05	4.511E-04	CYP1A2, CYP1A1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.204E-04	7.677E-03	CYP1A2, CYP1A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.724E-04	5.357E-03	CYP1A2, ALOX15
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.371E-03	1.348E-02	CYP1A2, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.725E-03	1.454E-02	CYP1A2, CYP1A1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.243E-03	2.503E-02	CYP1A2
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	8.133E-04	9.597E-03	CYP1A1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	2.550E-03	1.671E-02	AR, TP53
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.170E-03	1.600E-02	CYP1A2, CYP1A1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Prostate cancer	C61	AR;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;
C00-D49: Neoplasms	Bladder cancer	C67	AR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Female androgenresponsive recurrent mammary cancer	C50	AR;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	AR;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	AR;

Showing 1 to 10 of 40 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Schkuhria multiflora

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities