Plant Name: Schkuhria multiflora
Taxonomic Information:
Plant ID: NPO17647
Plant Latin Name: Schkuhria multiflora
Taxonomy Genus: Schkuhria
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| CA2; CA12; CA1; CA9; | |
| AR; | |
| ALOX15; HPGD; PARP1; TNKS2; TNKS; | |
| TP53; | |
| MAPT; RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | PARP1 | Poly [ADP-ribose] polymerase-1 | P09874 | CHEMBL3105 |
| Enzyme_unclassified | TNKS2 | Tankyrase-2 | Q9H2K2 | CHEMBL6154 |
| Enzyme_unclassified | TNKS | Tankyrase-1 | O95271 | CHEMBL6164 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Nuclear hormone receptor subfamily 3 group C | AR | Androgen Receptor | P10275 | CHEMBL1871 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 5.569E-10 | 6.064E-06 | CA1, CA12, CA2, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.376E-08 | 7.392E-05 | CA1, CA12, CA2, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 5.453E-08 | 1.484E-04 | CA1, CA12, CA2, CA9 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.650E-07 | 3.266E-04 | AR, CA1, CA12, CA2, CA9, PARP1, TNKS, TP53 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 9.919E-07 | 1.440E-03 | CYP19A1, CYP1A1, CYP1A2 |
| MF | GO:0003824; catalytic activity | GO:0003950; NAD+ ADP-ribosyltransferase activity | 1.454E-06 | 1.583E-03 | PARP1, TNKS, TNKS2 |
| BP | GO:0065007; biological regulation | GO:1904357; negative regulation of telomere maintenance via telomere lengthening | 1.635E-06 | 1.695E-03 | PARP1, TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0070213; protein auto-ADP-ribosylation | 4.370E-06 | 3.172E-03 | TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 4.370E-06 | 3.172E-03 | CYP1A1, CYP1A2 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 7.853E-06 | 5.344E-03 | CYP19A1, CYP1A1, CYP1A2 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 9.921E-06 | 6.209E-03 | ALOX15, CYP19A1, CYP1A1, CYP1A2 |
| BP | GO:0008152; metabolic process | GO:0070212; protein poly-ADP-ribosylation | 1.091E-05 | 6.254E-03 | PARP1, TNKS |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 1.091E-05 | 6.254E-03 | ALOX15, HPGD |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 1.091E-05 | 6.254E-03 | CA1, CA2 |
| BP | GO:0008152; metabolic process | GO:0050665; hydrogen peroxide biosynthetic process | 2.035E-05 | 9.847E-03 | CYP1A1, CYP1A2 |
| CC | GO:0016020; membrane | GO:0016020; membrane | 6.198E-05 | 2.142E-02 | ALOX15, AR, CA12, CA2, CA9, CYP19A1, CYP1A1, CYP1A2, HPGD, MAPT, NPC1, PARP1, RAB9A, TNKS, TNKS2 |
| CC | GO:0043226; organelle | GO:0000242; pericentriolar material | 1.372E-04 | 3.557E-02 | TNKS, TNKS2 |
| CC | GO:0043226; organelle | GO:0000784; nuclear chromosome, telomeric region | 1.934E-04 | 4.479E-02 | PARP1, TNKS, TNKS2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 8.442E-10 | 4.981E-08 | CA12, CA1, CA2, CA9 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.529E-05 | 4.511E-04 | CYP1A2, CYP1A1, CYP19A1 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 5.204E-04 | 7.677E-03 | CYP1A2, CYP1A1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.724E-04 | 5.357E-03 | CYP1A2, ALOX15 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 8.133E-04 | 9.597E-03 | CYP1A1, CYP19A1 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.371E-03 | 1.348E-02 | CYP1A2, CYP1A1 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 2.550E-03 | 1.671E-02 | AR, TP53 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.725E-03 | 1.454E-02 | CYP1A2, CYP1A1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 2.170E-03 | 1.600E-02 | CYP1A2, CYP1A1 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 4.243E-03 | 2.503E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| N00-N99: Diseases of the genitourinary system | Prostate hyperplasia | N40 | AR; |
| C00-D49: Neoplasms | Prostate cancer | C61 | AR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Muscle atrophy | M62.5 | AR; |
| K00-K95: Diseases of the digestive system | Alcoholic hepatitis | K70.1 | AR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | AR; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | AR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Testosterone deficiency | E29.1 | AR; |
| C00-D49: Neoplasms | Bladder cancer | C67 | AR; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | AR; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| Z00-Z99: Factors influencing health status and contact with health services | Contraception | Z30 | AR; |
| C00-D49: Neoplasms | Female androgenresponsive recurrent mammary cancer | C50 | AR; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypogonadism | E23.0, E28.3, E29.1 | AR; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Cystic fibrosis | E84 | AR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | AR; |
| C00-D49: Neoplasms | Hormone refractory prostate cancer | C61 | AR; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | AR; |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | AR; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | AR; |
| C00-D49: Neoplasms | Metastatic prostate cancer | C61 | AR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Endocrine disease | E00-E35 | AR; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis in post-menopausal women | M80-M81 | AR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Male hormonal deficiencies | E20-E35 | AR; |
| NA: NA | Male hypogonadism | NA | AR; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Alopecia | L65.9 | AR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatological disease | L00-L99 | AR; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| C00-D49: Neoplasms | Castration-resistant prostate cancer | C61 | AR; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| C00-D49: Neoplasms | Breast cancer | C50 | AR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Advanced prostate cancer | C61 | AR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | AR; TP53; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cachexia | R64 | AR; |
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