CMAUP Plant Collective Molecular Activities

Plant Name: Rabdosia excisa

Taxonomic Information:

Plant ID: NPO17628
Plant Latin Name: Rabdosia excisa
Taxonomy Genus: Isodon
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Protein Kinase	IGF1R; FLT3; AURKB; AXL; KDR; CDK1; PIM1; MET;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	ALOX12; NOX4; HSD17B10; POLB;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	7.086E-08	1.209E-04	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, NR1H4, PIM1
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	2.179E-07	2.636E-04	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	2.826E-07	3.077E-04	AURKB, FLT3, IGF1R, KDR, PIM1
MF	GO:0005488; binding	GO:0005524; ATP binding	4.533E-06	2.913E-03	AURKB, AXL, CDK1, FLT3, IGF1R, KDR, MET, PIM1
CC	GO:0043226; organelle	GO:0005876; spindle microtubule	8.671E-06	4.196E-03	AURKB, CDK1, POLB
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	1.179E-05	5.035E-03	FLT3, KDR
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	1.327E-05	5.254E-03	AXL, CDK1, CYP1B1
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	1.524E-05	5.624E-03	ALOX12, IGF1R, KDR, MET, NOX4
BP	GO:0009987; cellular process	GO:0071310; cellular response to organic substance	1.617E-05	5.681E-03	AXL, CYP1B1, FLT3, IGF1R, KDR, NOX4, NR1H4
BP	GO:0008152; metabolic process	GO:0051054; positive regulation of DNA metabolic process	1.784E-05	5.969E-03	AURKB, CDK1, IGF1R, NOX4
BP	GO:0032502; developmental process	GO:0007568; aging	2.453E-05	7.015E-03	AURKB, CDK1, NOX4, POLB
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	2.574E-05	7.164E-03	AXL, CDK1, FLT3
BP	GO:0008152; metabolic process	GO:0019752; carboxylic acid metabolic process	2.729E-05	7.257E-03	ALOX12, CYP1B1, HSD17B10, NOX4, NR1H4, PIM1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.284E-04	5.580E-03	KDR, MET, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	4.223E-04	5.580E-03	KDR, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	4.797E-04	5.580E-03	KDR, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	3.012E-04	5.580E-03	FLT3, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	5.936E-04	5.580E-03	KDR, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	6.299E-04	5.580E-03	CYP1B1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	8.182E-04	5.580E-03	FLT3, PIM1
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	8.704E-04	5.580E-03	KDR, MET, IGF1R
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	9.300E-04	5.580E-03	FLT3, KDR, MET
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.292E-03	5.710E-03	PIM1, CYP1B1, MET
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	1.920E-03	7.405E-03	KDR, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.266E-03	5.710E-03	MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.129E-03	5.710E-03	FLT3, MET
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.957E-03	9.981E-03	FLT3, MET, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.375E-03	5.710E-03	MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2.394E-03	8.618E-03	CDK1, IGF1R

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	CLL	NA	FLT3;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases