CMAUP Plant Collective Molecular Activities

Plant Name: Phytolacca americana

Taxonomic Information:

Plant ID: NPO17551
Plant Latin Name: Phytolacca americana
Taxonomy Genus: Phytolacca
Taxonomy Family: Phytolaccaceae

Plant External Links:

NCBI TaxonomyDB: 3527
Plant-of-the-World-Online: 323290-2

Used in Medicines:

Country/Region:

South Africa; India; United States; Vietnam; China; Laos

Traditional Medicine System:

TCM; Homeopathy

Medicinal Functions:

Alterative; Anodyne; Antiinflammatory; Antirheumatic; Antiviral; Cancer; Cathartic; Expectorant; Homeopathy; Hypnotic; Narcotic; Purgative

Geographical Distribution:

Turkey; Italy; France; Laos; Bolivia; Algeria; Cape Verde; China; Germany; Spain; Ukraine; Liberia; Netherlands; Mauritius; Morocco; Vietnam; Switzerland; Bulgaria; United States; Romania; Albania; Portugal; Mexico; Tunisia; South Africa; India; Lesotho; Austria; Greece; Hungary

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; CDC25B;
Enzyme_unclassified	TDP1; PLA2G1B; ALOX12; GFER; AKR1B10; POLB;
Protein Kinase	SYK;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Unclassified	MAPT; GMNN; LMNA; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	SYK	Tyrosine-protein kinase SYK	P43405	CHEMBL2599
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	GMNN	Geminin	O75496	CHEMBL1293278
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.929E-06	1.500E-02	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	2.067E-06	1.500E-02	ALOX12, PLA2G1B, SYK
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.929E-06	1.500E-02	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0046456; icosanoid biosynthetic process	3.561E-06	1.679E-02	ALOX12, PLA2G1B, SYK
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	3.856E-06	1.679E-02	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	8.394E-06	2.814E-02	NR1H4, PTPN1, PTPN2
MF	GO:0005488; binding	GO:0032052; bile acid binding	2.308E-05	4.569E-02	NR1H4, PLA2G1B

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.103E-03	4.965E-02	PLA2G1B, ALOX12
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.141E-02	1.309E-01	POLB, SYK
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.727E-02	1.309E-01	MAPT, CDC25B
09100 Metabolism	09103 Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1.982E-02	1.309E-01	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.296E-02	1.309E-01	PLA2G1B
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.374E-02	1.309E-01	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2.842E-02	1.309E-01	AKR1B10
09150 Organismal Systems	09151 Immune system	hsa04664	Fc epsilon RI signaling pathway	5.305E-02	1.309E-01	SYK
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7.561E-02	1.309E-01	CDC25B
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	7.189E-02	1.309E-01	SYK

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases