CMAUP Plant Collective Molecular Activities

Plant Name: Uvaria chamae

Taxonomic Information:

Plant ID: NPO17534
Plant Latin Name: Uvaria chamae
Taxonomy Genus: Uvaria
Taxonomy Family: Annonaceae

Plant External Links:

NCBI TaxonomyDB: 174970
Plant-of-the-World-Online: 75615-1

Used in Medicines:

Country/Region:

Togo; Nigeria; China

Traditional Medicine System:

TCM

Geographical Distribution:

Ghana; Liberia; Chad; Sudan; Gambia; Mali; Burkina Faso; Togo; Senegal; China; Sierra Leone; Guinea-Bissau; Guinea; Nigeria; Cameroon; Cote d'Ivoire; Benin

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Transient receptor potential channel	TRPA1;
Enzyme_unclassified	ALOX15;
Oxidoreductase	PTGS1;
Unclassified	LMNA; HTT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006636; unsaturated fatty acid biosynthetic process	2.170E-05	3.873E-01	ALOX15, PTGS1
BP	GO:0008152; metabolic process	GO:0046456; icosanoid biosynthetic process	3.557E-05	3.873E-01	ALOX15, PTGS1
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	7.630E-05	4.419E-01	ALOX15, PTGS1
MF	GO:0003824; catalytic activity	GO:0051213; dioxygenase activity	2.127E-04	4.419E-01	ALOX15, PTGS1
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	5.177E-04	4.901E-01	PTGS1
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	5.177E-04	4.901E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	7.764E-04	4.972E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	7.764E-04	4.972E-01	ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	7.764E-04	4.972E-01	ALOX15
CC	GO:0044464; cell part	GO:0032421; stereocilium bundle	1.294E-03	6.551E-01	TRPA1
CC	GO:0016020; membrane	GO:0031090; organelle membrane	2.225E-02	1.000E+00	HTT, LMNA, PTGS1
CC	GO:0044425; membrane part	GO:0019897; extrinsic component of plasma membrane	2.664E-02	1.000E+00	ALOX15
CC	GO:0044464; cell part	GO:0005770; late endosome	3.446E-02	1.000E+00	HTT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.399E-05	1.128E-03	ALOX15, PTGS1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.074E-04	1.844E-03	ALOX15, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.230E-03	2.892E-02	ALOX15
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.392E-02	3.640E-02	PTGS1
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2.426E-02	3.640E-02	TRPA1
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.837E-02	3.640E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	2.058E-02	3.640E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	2.230E-02	3.640E-02	LMNA
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.382E-02	3.765E-02	ALOX15, PTGS1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.452E-02	3.765E-02	LMNA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases