CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	OPRD1; TACR2;
Small molecule receptor (family A GPCR)	HTR2C; DRD3;
Protein Phosphatase	PTPN1;
Enzyme_unclassified	MTOR; HSD17B10; ALDH1A1; USP2;
Protein Kinase	MERTK;
Nuclear hormone receptor subfamily 1 group A	THRB;
Aspartic protease	BACE1;
Transcription Factor	TP53;
Endoplasmic reticular retrotranslocon family	VCP;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	NPC1; RAB9A; LMNA; TUBB3; MCL1; MAPT; PMP22; GMNN;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Endoplasmic reticular retrotranslocon family	VCP	Transitional endoplasmic reticulum ATPase	P55072	CHEMBL1075145
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236

Showing 1 to 10 of 26 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1901216; positive regulation of neuron death	3.820E-06	2.898E-02	MAPT, MCL1, MTOR, TP53
BP	GO:0007610; behavior	GO:0007626; locomotory behavior	4.422E-06	2.898E-02	DRD3, HTR2C, NPC1, OPRD1, USP2
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	1.265E-05	3.443E-02	LMNA, MTOR, OPRD1, TP53
CC	GO:0044464; cell part	GO:0042995; cell projection	9.655E-06	3.003E-02	BACE1, DRD3, MAPT, MERTK, MTOR, OPRD1, SMN1, SMN2, TACR2, TUBB3
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	7.795E-06	2.898E-02	MAPT, PTPN1, TP53

Showing 1 to 5 of 5 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
No data available in table

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
A00-B99: Certain infectious and parasitic diseases	Dutch elm disease	B81-B83	MTOR;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1;
C00-D49: Neoplasms	Pancreatic cancer	C25	MTOR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MTOR;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MTOR;
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	MTOR;
C00-D49: Neoplasms	Bladder cancer	C67	MTOR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MTOR;
C00-D49: Neoplasms	Lymphoma	C81-C86	MTOR;

Showing 1 to 10 of 42 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Torreya nuncifera

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities