Plant Name: Pouteria sapota
Taxonomic Information:
Plant ID: NPO17462
Plant Latin Name: Pouteria sapota
Taxonomy Genus: Pouteria
Taxonomy Family: Sapotaceae
Plant External Links:
NCBI TaxonomyDB:
233744
Plant-of-the-World-Online:
n.a.
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| PTPN1; CDC25B; PTPN2; | |
| PLA2G1B; GFER; AKR1B10; POLB; APEX1; | |
| GAA; | |
| PIM1; | |
| NR1H4; | |
| KDM4E; | |
| RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 5.629E-07 | 7.689E-03 | APEX1, POLB |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 1.688E-06 | 7.689E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 1.688E-06 | 7.689E-03 | GPBAR1, NR1H4 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 3.374E-06 | 1.225E-02 | PTPN1, PTPN2 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 6.832E-06 | 1.860E-02 | NR1H4, PTPN1, PTPN2 |
| MF | GO:0005488; binding | GO:0032052; bile acid binding | 2.020E-05 | 4.398E-02 | NR1H4, PLA2G1B |
| BP | GO:0009987; cellular process | GO:1903897; regulation of PERK-mediated unfolded protein response | 2.524E-05 | 4.996E-02 | PTPN1, PTPN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 2.256E-04 | 4.239E-03 | AKR1B10, GAA |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 2.735E-04 | 4.239E-03 | POLB, APEX1 |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 3.738E-03 | 3.863E-02 | NPC1, GAA |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 6.087E-03 | 4.717E-02 | PIM1, PTPN2 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 2.031E-02 | 9.187E-02 | PIM1, CDC25B |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00592 | alpha-Linolenic acid metabolism | 1.859E-02 | 9.187E-02 | PLA2G1B |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.154E-02 | 9.187E-02 | PLA2G1B |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 2.667E-02 | 9.187E-02 | AKR1B10 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 2.374E-02 | 9.187E-02 | AKR1B10 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00565 | Ether lipid metabolism | 3.324E-02 | 9.366E-02 | PLA2G1B |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | CDC25B; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
