CMAUP Plant Collective Molecular Activities

Plant Name: Agathosma betulina

Taxonomic Information:

Plant ID: NPO17447
Plant Latin Name: Agathosma betulina
Taxonomy Genus: Agathosma
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: 770863-1

Used in Medicines:

Country/Region:

Madagascar; Zimbabwe; Angola; Swaziland; South Africa

Traditional Medicine System:

Geographical Distribution:

Madagascar; Zimbabwe; Angola; Swaziland; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA13; CA12; CA9;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.789E-10	8.250E-06	CA12, CA13, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.945E-09	6.473E-05	CA12, CA13, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.103E-08	8.004E-05	CA12, CA13, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.430E-05	1.798E-01	CA12, CA13, CA9
BP	GO:0009987; cellular process	GO:0043620; regulation of DNA-templated transcription in response to stress	1.822E-02	1.000E+00	CA9
BP	GO:0032502; developmental process	GO:0002009; morphogenesis of an epithelium	4.316E-02	1.000E+00	CA9
CC	GO:0044464; cell part	GO:0043209; myelin sheath	2.266E-02	1.000E+00	CA13
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.861E-02	1.000E+00	CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.101E-10	5.101E-10	CA12, CA9, CA13

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases