CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Miscellaneous ion channel	BCL2;
Enzyme_unclassified	P4HB; AKR1B1;
Aspartic protease	BACE1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Enzyme_unclassified	P4HB	Protein disulfide-isomerase	P07237	CHEMBL5422
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860

Showing 1 to 4 of 4 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0006979; response to oxidative stress	2.191E-05	3.006E-01	AKR1B1, BCL2, P4HB
BP	GO:0008152; metabolic process	GO:0018958; phenol-containing compound metabolic process	9.608E-05	3.006E-01	AKR1B1, BCL2
BP	GO:0032501; multicellular organismal process	GO:0003014; renal system process	1.457E-04	3.006E-01	AKR1B1, BCL2
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	1.711E-04	3.006E-01	BCL2, P4HB
BP	GO:0050896; response to stimulus	GO:0042542; response to hydrogen peroxide	1.845E-04	3.006E-01	AKR1B1, BCL2
MF	GO:0005488; binding	GO:0051434; BH3 domain binding	1.035E-03	4.691E-01	BCL2

Showing 1 to 6 of 6 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.987E-03	4.163E-02	AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6.385E-03	4.163E-02	AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.175E-02	4.163E-02	AKR1B1
09120 Genetic Information Processing	09123 Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	4.212E-04	1.179E-02	BCL2, P4HB
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	2.379E-02	4.163E-02	BCL2
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	1.234E-02	4.163E-02	BCL2
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	1.016E-02	4.163E-02	BCL2
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.768E-02	4.163E-02	BCL2
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.005E-02	4.163E-02	BCL2
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	1.709E-02	4.163E-02	BCL2

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2;
C00-D49: Neoplasms	Leukemia	C90-C95	BCL2;
C00-D49: Neoplasms	Multiple myeloma	C90	BCL2;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
C00-D49: Neoplasms	Prostate cancer	C61	BCL2;
C00-D49: Neoplasms	Cancer	C00-C96	BCL2;
C00-D49: Neoplasms	Breast cancer	C50	BCL2;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	BCL2;

Showing 1 to 10 of 10 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cassia kleinii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities