Plant Name: Cassia kleinii
Taxonomic Information:
Plant ID: NPO17446
Plant Latin Name: Cassia kleinii
Taxonomy Genus: Cassia
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| BCL2; | |
| P4HB; AKR1B1; | |
| BACE1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| Enzyme_unclassified | P4HB | Protein disulfide-isomerase | P07237 | CHEMBL5422 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0006979; response to oxidative stress | 2.191E-05 | 3.006E-01 | AKR1B1, BCL2, P4HB |
| BP | GO:0008152; metabolic process | GO:0018958; phenol-containing compound metabolic process | 9.608E-05 | 3.006E-01 | AKR1B1, BCL2 |
| BP | GO:0032501; multicellular organismal process | GO:0003014; renal system process | 1.457E-04 | 3.006E-01 | AKR1B1, BCL2 |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.711E-04 | 3.006E-01 | BCL2, P4HB |
| BP | GO:0050896; response to stimulus | GO:0042542; response to hydrogen peroxide | 1.845E-04 | 3.006E-01 | AKR1B1, BCL2 |
| MF | GO:0005488; binding | GO:0051434; BH3 domain binding | 1.035E-03 | 4.691E-01 | BCL2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09120 Genetic Information Processing | 09123 Folding, sorting and degradation | hsa04141 | Protein processing in endoplasmic reticulum | 4.212E-04 | 1.179E-02 | BCL2, P4HB |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 5.987E-03 | 4.163E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 6.385E-03 | 4.163E-02 | AKR1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 1.175E-02 | 4.163E-02 | AKR1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 1.234E-02 | 4.163E-02 | BCL2 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 1.016E-02 | 4.163E-02 | BCL2 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.768E-02 | 4.163E-02 | BCL2 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2.005E-02 | 4.163E-02 | BCL2 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 1.709E-02 | 4.163E-02 | BCL2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 2.379E-02 | 4.163E-02 | BCL2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Lymphoma | C81-C86 | BCL2; |
| C00-D49: Neoplasms | Leukemia | C90-C95 | BCL2; |
| G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | BCL2; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | BCL2; |
| C00-D49: Neoplasms | Advanced melanoma | C43 | BCL2; |
| C00-D49: Neoplasms | Prostate cancer | C61 | BCL2; |
| C00-D49: Neoplasms | Cancer | C00-C96 | BCL2; |
| C00-D49: Neoplasms | Breast cancer | C50 | BCL2; |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | BCL2; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | BCL2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
