Plant Name: Thryptomene kochii
Taxonomic Information:
Plant ID: NPO17440
Plant Latin Name: Thryptomene kochii
Taxonomy Genus: Thryptomene
Taxonomy Family: Myrtaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| NR1H4; | |
| ELANE; | |
| MAPT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Serine protease | ELANE | Leukocyte elastase | P08246 | CHEMBL248 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0032682; negative regulation of chemokine production | 2.459E-06 | 5.355E-02 | ELANE, NR1H4 |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 1.050E-04 | 1.353E-01 | ELANE, NR1H4 |
| MF | GO:0140110; transcription regulator activity | GO:0001076; transcription factor activity, RNA polymerase II transcription factor binding | 1.909E-04 | 1.485E-01 | ELANE, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 4.659E-04 | 2.359E-01 | NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.087E-03 | 3.242E-01 | NR1H4 |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 1.708E-03 | 3.610E-01 | MAPT |
| MF | GO:0005488; binding | GO:0046965; retinoid X receptor binding | 2.328E-03 | 4.121E-01 | NR1H4 |
| CC | GO:0044464; cell part | GO:0030673; axolemma | 2.483E-03 | 4.191E-01 | MAPT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 3.345E-02 | NR1H4 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05322 | Systemic lupus erythematosus | 2.011E-02 | 3.345E-02 | ELANE |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.499E-02 | 3.345E-02 | MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 3.777E-02 | 3.777E-02 | MAPT |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 2.676E-02 | 3.345E-02 | ELANE |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
