CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	HPGD;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	6.212E-04	9.705E-01	HPGD
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	6.212E-04	9.705E-01	CYP2C9
BP	GO:0008152; metabolic process	GO:0070988; demethylation	6.100E-03	1.000E+00	CYP2C9
BP	GO:0008283; cell proliferation	GO:0048661; positive regulation of smooth muscle cell proliferation	7.854E-03	1.000E+00	HPGD
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.917E-02	1.000E+00	HPGD
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.141E-04	9.705E-01	CYP2C9
MF	GO:0005488; binding	GO:0048037; cofactor binding	6.240E-04	9.705E-01	CYP2C9, HPGD
MF	GO:0003824; catalytic activity	GO:0016614; oxidoreductase activity, acting on CH-OH group of donors	1.403E-02	1.000E+00	HPGD
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.650E-02	1.000E+00	CYP2C9

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.898E-03	1.228E-02	CYP2C9
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	6.191E-03	1.228E-02	CYP2C9
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6.490E-03	1.228E-02	CYP2C9
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.888E-03	1.228E-02	CYP2C9
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.287E-03	1.228E-02	CYP2C9
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.117E-02	1.436E-02	CYP2C9
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	8.183E-03	1.228E-02	CYP2C9
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	1.792E-02	2.016E-02	HPGD
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.201E-01	1.201E-01	CYP2C9

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Solanum coccineum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities