CMAUP Plant Collective Molecular Activities

Plant Name: Asperula odorata

Taxonomic Information:

Plant ID: NPO17395
Plant Latin Name: Asperula odorata
Taxonomy Genus: Asperula
Taxonomy Family: Rubiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Albania; China

Traditional Medicine System:

TCM

Geographical Distribution:

Albania; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; RECQL; ALOX15; HSD17B10; ALOX12;
Miscellaneous ion channel	BCL2;
Unclassified	MCL1; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	1.930E-07	1.051E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	1.930E-07	1.051E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	5.788E-07	2.101E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	5.788E-07	2.101E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	1.928E-06	4.666E-03	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0051434; BH3 domain binding	1.928E-06	4.666E-03	BCL2, MCL1
BP	GO:0008152; metabolic process	GO:0010507; negative regulation of autophagy	3.935E-06	7.789E-03	BCL2, MCL1, NPC1
BP	GO:0009987; cellular process	GO:2000811; negative regulation of anoikis	2.308E-05	2.758E-02	BCL2, MCL1
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	2.308E-05	2.758E-02	ALOX12, ALOX15
CC	GO:0032991; macromolecular complex	GO:0097136; Bcl-2 family protein complex	2.793E-03	4.985E-01	MCL1
CC	GO:0044464; cell part	GO:0005737; cytoplasm	4.532E-03	6.168E-01	ALOX12, BCL2, HSD17B10, MCL1, RECQL, TDP1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.357E-04	1.041E-02	ALOX15, ALOX12
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.091E-03	1.668E-02	ALOX15, ALOX12
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.696E-03	1.668E-02	BCL2, MCL1
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	2.153E-03	1.668E-02	BCL2, MCL1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	9.640E-03	4.981E-02	BCL2, MCL1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	7.385E-03	4.579E-02	BCL2, MCL1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.502E-02	5.821E-02	ALOX15, ALOX12, HSD17B10
09100 Metabolism	09105 Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2.140E-02	7.044E-02	HSD17B10
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.298E-02	5.747E-02	ALOX15
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	2.272E-02	7.044E-02	BCL2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases