CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; CDC25B; PTPN2;
Enzyme_unclassified	TDP1; PLA2G1B; RECQL; ALDH1A1; AKR1B10; AKR1B1; POLB;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	PTGS1;
Aspartic protease	BACE1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2A6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392

Showing 1 to 10 of 18 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	2.455E-06	1.785E-02	AKR1B1, AKR1B10, CYP2A6, CYP3A4, NR1H4
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	2.459E-06	1.785E-02	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	4.916E-06	2.507E-02	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	1.219E-05	3.745E-02	NR1H4, PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0044597; daunorubicin metabolic process	2.289E-05	4.153E-02	AKR1B1, AKR1B10
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	2.459E-06	1.785E-02	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	8.786E-06	3.189E-02	AKR1B1, AKR1B10, ALDH1A1
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	1.718E-05	4.153E-02	AKR1B10, ALDH1A1
MF	GO:0005488; binding	GO:0032052; bile acid binding	2.941E-05	4.268E-02	NR1H4, PLA2G1B

Showing 1 to 9 of 9 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.582E-05	1.162E-03	CYP2A6, ALDH1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.062E-04	3.361E-03	PLA2G1B, CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4.733E-04	3.550E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	3.279E-04	3.361E-03	AKR1B10, AKR1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7.735E-04	4.972E-03	CYP2A6, CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3.734E-04	3.361E-03	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.270E-03	6.305E-03	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.401E-03	6.305E-03	PLA2G1B, PTGS1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.732E-03	6.701E-03	CYP2A6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.936E-03	6.701E-03	CYP2A6, CYP3A4

Showing 1 to 10 of 14 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Aconitum sajanense

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities