CMAUP Plant Collective Molecular Activities

Plant Name: Chrysanthemum zawadskii

Taxonomic Information:

Plant ID: NPO17295
Plant Latin Name: Chrysanthemum zawadskii
Taxonomy Genus: Chrysanthemum
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 147003
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Korea

Traditional Medicine System:

Geographical Distribution:

South Korea

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Transient receptor potential channel	TRPA1;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	TP53;
Unclassified	MAPT; FABP3; LMNA; FABP2; FABP4; FABP5;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.949E-09	2.141E-05	FABP2, FABP3, FABP4, FABP5
MF	GO:0005488; binding	GO:0019902; phosphatase binding	6.357E-06	5.537E-03	MAPK1, MAPT, PPARA, TP53
MF	GO:0005488; binding	GO:0097371; MDM2/MDM4 family protein binding	1.179E-05	9.172E-03	PPARA, TP53
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.762E-05	1.279E-02	FABP3, PPARA, PPARD
BP	GO:0051179; localization	GO:0006810; transport	2.142E-05	1.434E-02	FABP3, FABP5, LMNA, MAPK1, MAPT, PPARA, PPARD, SMN1, SMN2, TLR2, TRPA1
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	2.174E-05	1.434E-02	FABP5, LMNA, MAPK1, PPARA, PPARD, SMN1, SMN2, TLR2, TP53, TSHR
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	3.083E-05	1.815E-02	FABP3, PPARD
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	3.698E-05	2.119E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	4.369E-05	2.378E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	8.550E-05	3.724E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0043204; perikaryon	8.878E-05	3.791E-02	MAPK1, SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.592E-12	7.911E-10	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.436E-04	4.878E-03	LMNA, MAPK1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.234E-04	4.878E-03	MAPK1, PPARA, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.626E-04	4.878E-03	MAPK1, TP53, TLR2
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.284E-04	6.427E-03	MAPK1, TP53, TLR2
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	4.042E-04	6.427E-03	MAPK1, PPARA, TSHR
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.107E-04	5.056E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	4.233E-04	6.427E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	6.813E-04	7.681E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	7.898E-04	7.681E-03	MAPK1, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	8.321E-04	7.681E-03	MAPK1, MAPT, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7.898E-04	7.681E-03	FABP4, TSHR
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	8.182E-04	7.681E-03	MAPK1, PPARD
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.063E-03	7.967E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	9.673E-04	7.967E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.095E-03	7.967E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.266E-03	8.028E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.129E-03	7.967E-03	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.338E-03	8.028E-03	MAPK1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	1.338E-03	8.028E-03	MAPK1, TLR2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases