Plant Name: Cotoneaster simonsii
Taxonomic Information:
Plant ID: NPO17272
Plant Latin Name: Cotoneaster simonsii
Taxonomy Genus: Cotoneaster
Taxonomy Family: Rosaceae
Plant External Links:
NCBI TaxonomyDB:
1572675
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| FAAH; TERT; IDO1; | |
| PPARA; PPARD; PPARG; | |
| PTGS2; ALOX5; | |
| TLR2; | |
| LMNA; FABP3; RAB9A; FABP2; NPC1; FABP4; FABP5; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | FAAH | Anandamide amidohydrolase | O00519 | CHEMBL2243 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | IDO1 | Indoleamine 2,3-dioxygenase | P14902 | CHEMBL4685 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Oxidoreductase | PTGS2 | Cyclooxygenase-2 | P35354 | CHEMBL230 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 5.134E-09 | 9.039E-06 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0008283; cell proliferation | GO:0008285; negative regulation of cell proliferation | 5.435E-08 | 6.219E-05 | FABP3, IDO1, LMNA, PPARD, PPARG, PTGS2, TERT, TLR2 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 3.041E-07 | 2.365E-04 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 6.231E-07 | 4.240E-04 | FABP3, PPARG, PTGS2, TLR2 |
| BP | GO:0032501; multicellular organismal process | GO:0001816; cytokine production | 7.228E-07 | 4.727E-04 | FABP4, IDO1, PTGS2, TLR2 |
| MF | GO:0003824; catalytic activity | GO:0016702; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | 1.454E-06 | 7.537E-04 | ALOX5, IDO1, PTGS2 |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.788E-06 | 8.653E-04 | LMNA, PPARD, PTGS2, TERT |
| BP | GO:0050896; response to stimulus | GO:0050729; positive regulation of inflammatory response | 2.581E-06 | 1.059E-03 | FABP4, IDO1, PTGS2, TLR2 |
| BP | GO:0008283; cell proliferation | GO:0048660; regulation of smooth muscle cell proliferation | 4.095E-06 | 1.511E-03 | PPARD, PPARG, PTGS2, TERT |
| BP | GO:0050896; response to stimulus | GO:0032868; response to insulin | 5.683E-06 | 1.996E-03 | FABP3, PPARA, PPARG, TLR2 |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 7.279E-06 | 2.516E-03 | PPARA, PPARG |
| BP | GO:0009987; cellular process | GO:0060548; negative regulation of cell death | 8.816E-06 | 2.953E-03 | IDO1, LMNA, NPC1, PPARA, PPARD, PTGS2, TERT |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.017E-05 | 3.307E-03 | PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 1.091E-05 | 3.358E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 1.091E-05 | 3.358E-03 | PPARA, PPARG |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 1.091E-05 | 3.358E-03 | FABP3, PPARG |
| BP | GO:0009987; cellular process | GO:0045600; positive regulation of fat cell differentiation | 1.785E-05 | 5.116E-03 | PPARD, PPARG, PTGS2 |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 1.785E-05 | 5.116E-03 | PPARA, PPARD, PPARG |
| BP | GO:0032501; multicellular organismal process | GO:0002532; production of molecular mediator involved in inflammatory response | 2.035E-05 | 5.681E-03 | ALOX5, IDO1 |
| BP | GO:0065007; biological regulation | GO:0042632; cholesterol homeostasis | 2.504E-05 | 6.731E-03 | FABP3, FABP4, NPC1 |
| MF | GO:0005488; binding | GO:0001223; transcription coactivator binding | 1.372E-04 | 2.596E-02 | PPARA, TERT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 8.049E-14 | 4.588E-12 | FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.375E-05 | 3.919E-04 | FABP4, PTGS2, TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 8.133E-04 | 1.545E-02 | ALOX5, PTGS2 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.248E-03 | 1.778E-02 | ALOX5, PTGS2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 1.725E-03 | 1.966E-02 | PTGS2, TLR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 4.292E-03 | 2.806E-02 | PPARG, PTGS2, PPARD |
| 09150 Organismal Systems | 09156 Nervous system | hsa04723 | Retrograde endocannabinoid signaling | 3.268E-03 | 2.806E-02 | FAAH, PTGS2 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 4.001E-03 | 2.806E-02 | ALOX5, PTGS2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 4.430E-03 | 2.806E-02 | ALOX5, TLR2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 5.839E-03 | 3.328E-02 | RAB9A, TLR2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | PTGS2; ALOX5; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Chronic pain | R52.1-R52.2, G89 | PTGS2; |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | ALOX5; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | PTGS2; |
| K00-K95: Diseases of the digestive system | Colon polyps | K63.5 | PTGS2; |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | PTGS2; ALOX5; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | ALOX5; |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | ALOX5; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PTGS2; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | ALOX5; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | PTGS2; |
| NA: NA | Rheumatold arthritis | NA | PTGS2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTGS2; |
| J00-J99: Diseases of the respiratory system | Respiratory disease | J00-J99 | ALOX5; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Knee osteoarthritis | M15-M19, M47 | PTGS2; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Ankylosing spondylitis | M08.1, M45 | PTGS2; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | ALOX5; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Hyperthermia | T68 | PTGS2; |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PTGS2; ALOX5; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | PTGS2; ALOX5; |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTGS2; |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | PTGS2; |
| J00-J99: Diseases of the respiratory system | Rhinitis | J00, J30, J31.0 | ALOX5; |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | PTGS2; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | PTGS2; ALOX5; |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | PTGS2; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | PTGS2; |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | ALOX5; |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PTGS2; ALOX5; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Moderate to severe rheumatoid arthritis | M05-M06 | PTGS2; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | ALOX5; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | ALOX5; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | PTGS2; |
| C00-D49: Neoplasms | Cancer | C00-C96 | PTGS2; |
| NA: NA | Joint and muscular pain | NA | PTGS2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
