Plant ID: NPO17231
Plant Latin Name: Pycnarrhena australiana
Taxonomy Genus: Pycnarrhena
Taxonomy Family: Menispermaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 4.823E-07 | 1.050E-02 | CYP1A2, CYP2C19 |
BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 1.447E-06 | 1.540E-02 | CYP1A2, CYP2C19 |
BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 2.121E-06 | 1.540E-02 | CYP1A2, CYP2C19 |
BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 6.746E-06 | 3.672E-02 | CYP1A2, CYP2C19 |
MF | GO:0005488; binding | GO:0019825; oxygen binding | 3.175E-05 | 1.383E-01 | CYP1A2, CYP2C19 |
MF | GO:0003824; catalytic activity | GO:0004497; monooxygenase activity | 1.427E-04 | 2.652E-01 | CYP1A2, CYP2C19 |
MF | GO:0005488; binding | GO:0020037; heme binding | 2.592E-04 | 2.970E-01 | CYP1A2, CYP2C19 |
MF | GO:0003824; catalytic activity | GO:0016705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 3.798E-04 | 3.468E-01 | CYP1A2, CYP2C19 |
MF | GO:0005488; binding | GO:0005506; iron ion binding | 4.047E-04 | 3.468E-01 | CYP1A2, CYP2C19 |
MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 4.141E-04 | 3.468E-01 | TSHR |
MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 8.281E-04 | 5.635E-01 | CYP1A2 |
CC | GO:0016020; membrane | GO:0031090; organelle membrane | 9.939E-03 | 1.000E+00 | CYP1A2, CYP2C19, LMNA |
CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 1.278E-02 | 1.000E+00 | CYP1A2, CYP2C19 |
CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 3.333E-02 | 1.000E+00 | LMNA |
CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 3.797E-02 | 1.000E+00 | TSHR |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.216E-05 | 2.432E-04 | CYP1A2, CYP2C19 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 7.007E-05 | 6.607E-04 | CYP1A2, CYP2C19 |
09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 9.910E-05 | 6.607E-04 | CYP1A2, CYP2C19 |
09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 1.056E-02 | 2.264E-02 | TSHR |
09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.155E-02 | 2.264E-02 | CYP1A2 |
09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.294E-02 | 2.264E-02 | CYP1A2 |
09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.413E-02 | 2.264E-02 | TSHR |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.452E-02 | 2.264E-02 | CYP1A2 |
09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.472E-02 | 2.264E-02 | LMNA |
09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 9.997E-04 | 4.999E-03 | CYP1A2 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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