CMAUP Plant Collective Molecular Activities

Plant Name: Impatiens siculifer

Taxonomic Information:

Plant ID: NPO17203
Plant Latin Name: Impatiens siculifer
Taxonomy Genus: Impatiens
Taxonomy Family: Balsaminaceae

Plant External Links:

NCBI TaxonomyDB: 253054
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;
Protein Kinase	CSNK2A1;
Lyase	CA14; CA12; CA9;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Enzyme_unclassified	HSD17B1;
Unclassified	THPO; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.084E-09	1.991E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.809E-08	1.313E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.850E-08	1.551E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.078E-07	3.914E-04	CA12, CA14, CA9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.145E-07	8.675E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.185E-07	8.675E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0020037; heme binding	1.256E-06	1.953E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.507E-06	3.211E-03	CYP1A1, CYP1A2
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.104E-06	3.380E-03	CA12, CA14, CA9
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.059E-06	3.380E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.168E-05	9.783E-03	CYP1A1, CYP1A2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.712E-23	1.185E-20	CA12, CA1, CA3, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.423E-09	5.047E-07	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.713E-07	7.765E-06	HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.202E-06	8.711E-05	MAOA, CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.075E-06	7.054E-05	CYP1A2, CYP1A1, CYP1B1, CYP3A4, PTGS2
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.264E-05	4.960E-04	CYP1A2, ALDH1A1, CYP1A1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.553E-05	4.960E-04	PKM, FLT3, TP53, HIF1A
Unclassified	Unclassified	hsa01100	Metabolic pathways	5.037E-05	6.637E-04	PKM, MAOA, HSD17B1, CYP1A2, ALOX15, ALDH1A1, CYP1A1, PTGS2, CYP3A4, CYP19A1, HSD17B10, XDH
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	6.281E-05	6.637E-04	AR, GSK3B, CDK6, FLT3, PTGS2, HIF1A, TP53
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.585E-05	5.417E-04	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.212E-05	5.417E-04	CA2, CYP3A4, CFTR, ABCG2
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.323E-04	2.106E-03	GSK3B, TP53, ESR1, HIF1A
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	3.990E-04	3.392E-03	GSK3B, CDK6, CSNK2A1, TP53
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.447E-05	6.637E-04	CYP1A2, ALOX15, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	9.380E-04	6.379E-03	ABCC1, CDK6, CYP1B1, PTGS2, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	8.230E-04	6.218E-03	GSK3B, ESR1, ESR2
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	8.826E-04	6.318E-03	GSK3B, CASP7, MAPT, HSD17B10
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	1.922E-04	1.867E-03	ABCC1, CFTR, ABCG2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.269E-04	5.815E-03	MAOA, CYP1A2, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	1.742E-03	9.870E-03	GSK3B, SYK, CSNK2A1, TP53
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.520E-03	9.397E-03	GSK3B, AR, TP53
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.838E-03	9.999E-03	CDK6, PKM, SYK, TP53
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	1.377E-03	8.920E-03	CDK6, PTGS2, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	1.725E-03	9.870E-03	SYK, CSNK2A1, PTGS2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	6.344E-05	6.637E-04	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1; CA9;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; ACHE; CA9;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases