CMAUP Plant Collective Molecular Activities

Plant Name: Callicarpa pilosissima

Taxonomic Information:

Plant ID: NPO17126
Plant Latin Name: Callicarpa pilosissima
Taxonomy Genus: Callicarpa
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Protein Kinase	CDK8; CDK9;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Enzyme_unclassified	ALDH1A1;
Aspartic protease	CTSD;
Transcription Factor	HIF1A;
ATP-binding cassette	ABCG2;
Unclassified	NPC1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	CTSD	Cathepsin D	P07339	CHEMBL2581
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	CDK8	Cell division protein kinase 8	P49336	CHEMBL5719
Protein Kinase	CDK9	Cyclin-dependent kinase 9	P50750	CHEMBL3116
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.945E-14	5.041E-10	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.372E-12	7.469E-09	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.576E-12	2.232E-08	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	6.150E-12	2.232E-08	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.023E-10	4.405E-07	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	8.772E-10	1.469E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.264E-09	2.738E-06	CYP1A2, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.374E-09	3.499E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.597E-09	3.561E-06	CYP1A1, CYP1A2, CYP1B1, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.240E-07	7.498E-05	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	9.919E-07	5.070E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0001523; retinoid metabolic process	1.001E-06	5.070E-04	ALDH1A1, CYP1A1, CYP1B1, PPARD
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	2.186E-06	9.520E-04	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.370E-06	1.669E-03	CYP1A1, CYP1A2
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	6.993E-06	2.625E-03	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, RAB9A
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	7.279E-06	2.687E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	9.921E-06	3.562E-03	CDK8, CDK9, PPARA, PPARD
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.091E-05	3.833E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.527E-05	5.038E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.035E-05	6.422E-03	CYP1A1, CYP1A2
CC	GO:0016020; membrane	GO:0031090; organelle membrane	1.766E-04	4.134E-02	ABCG2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, NPC1, RAB9A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.707E-11	2.024E-09	CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.861E-09	4.001E-08	CYP2C9, CYP1A2, ALDH1A1, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.370E-09	4.831E-08	CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.372E-09	9.000E-08	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.984E-07	2.139E-06	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.473E-07	1.267E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.943E-06	3.036E-05	CYP1A2, CYP1A1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.819E-04	2.053E-03	CYP2C9, CYP1A2, ALDH1A1, CYP1A1, CYP2C19, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	8.133E-04	3.886E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.248E-03	5.366E-03	CYP2C9, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.543E-03	5.850E-03	PPARA, PPARD
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.633E-03	5.850E-03	CYP3A4, ABCG2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases