CMAUP Plant Collective Molecular Activities

Plant Name: Lonicera macranthoides

Taxonomic Information:

Plant ID: NPO17072
Plant Latin Name: Lonicera macranthoides
Taxonomy Genus: Lonicera
Taxonomy Family: Caprifoliaceae

Plant External Links:

NCBI TaxonomyDB: 638627
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	RECQL; AKR1B10; ALOX12; AKR1B1; HSD17B10; NOX4; POLB;
Hydrolase	ACHE;
Protein Phosphatase	CDC25B;
Protein Kinase	PIM1; MET; AXL; FLT3; CDK1; KDR; IGF1R; AURKB;
Lyase	CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP9; MMP1; MMP12; MMP2;
Transcription Factor	HIF1A; NFKB1;
SLC superfamily of solute carriers	SLCO1B3;
Unclassified	FABP4; APP;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	3.909E-07	2.580E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	1.109E-06	5.033E-04	HIF1A, MMP1, MMP12, MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.235E-06	9.011E-04	CA12, CA4, CA7
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	3.888E-06	1.388E-03	AKR1B1, AXL, CDK1, CYP1B1
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	5.019E-06	1.763E-03	MMP1, MMP12, MMP2, MMP9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	8.053E-06	2.505E-03	CA12, CA4, CA7, MMP1, MMP12, MMP2, MMP9, NR1H4, RORC
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	1.095E-05	3.156E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:1902751; positive regulation of cell cycle G2/M phase transition	1.116E-05	3.156E-03	APP, CDC25B, CDK1
BP	GO:0008152; metabolic process	GO:0010557; positive regulation of macromolecule biosynthetic process	1.468E-05	3.762E-03	APP, AURKB, CDK1, HIF1A, IGF1R, KDR, MET, MMP12, NFKB1, NOX4, NR1H4, RORC
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.740E-05	4.201E-03	AXL, FLT3, IGF1R, KDR, MET
MF	GO:0005488; binding	GO:0008144; drug binding	2.151E-05	4.854E-03	ACHE, AURKB, AXL, CDK1, CYP1B1, FLT3, IGF1R, KDR, MET, NOX4, PIM1, RECQL
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	2.239E-05	4.970E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0008152; metabolic process	GO:0031328; positive regulation of cellular biosynthetic process	2.930E-05	6.040E-03	APP, AURKB, CDK1, HIF1A, IGF1R, MET, MMP12, NFKB1, NOX4, NR1H4, RORC, TSHR
BP	GO:0050896; response to stimulus	GO:1901653; cellular response to peptide	2.978E-05	6.060E-03	AKR1B1, APP, IGF1R, NFKB1, TSHR
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	3.018E-05	6.086E-03	APP, CYP1B1, FLT3, NFKB1, NOX4, RORC
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.419E-05	6.830E-03	CA12, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	4.817E-05	8.955E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0065007; biological regulation	GO:0048872; homeostasis of number of cells	4.982E-05	9.117E-03	AXL, FLT3, HIF1A, POLB

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.124E-22	1.544E-19	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.750E-12	4.512E-10	CAMK2B, SRC, MMP2, PIK3R1, HIF1A, MMP9, PTK2, IGF1R, KDR, AKT1, MAPK1, TP53, MET, TLR2
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	4.147E-10	2.626E-08	GSK3B, FLT3, MMP1, DAPK1, MMP2, PIK3R1, HIF1A, MMP9, NFKB1, PTK2, IGF1R, AKT1, MAPK1, MET, TP53, PPARD
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.126E-09	1.010E-07	MMP1, DAPK1, SRC, MMP2, MAPK1, MMP9, TP53
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	6.236E-09	2.370E-07	PTPN1, CSNK2A1, SRC, MAPK1, ACP1, MET, PTPRF, IGF1R
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.329E-08	7.157E-07	FLT3, PIM1, AKT1, MAPK1, PIK3R1, NFKB1, PPARD
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	9.728E-08	1.848E-06	SRC, AKT1, MAPK1, STAT6, PIK3R1, TP53, MMP9, NFKB1, TLR2
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	7.329E-08	1.741E-06	FLT3, AKT1, MAPK1, PIK3R1, TP53, MET, HIF1A
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.637E-08	7.157E-07	HSD11B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	3.205E-07	4.684E-06	GSK3B, KDR, AKT1, MAPK1, PIK3R1, PKN1, TP53, MET, PTK2, NFKB1, TLR2, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.345E-07	2.324E-06	PTPN1, GSK3B, AKT1, PIK3R1, PYGL, PPARA, NFKB1, PTPRF
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	9.012E-08	1.848E-06	FABP2, FABP3, FABP4, FABP5, MMP1, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.824E-07	4.471E-06	ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	5.268E-07	6.256E-06	GSK3B, AKT1, MAPK1, PIK3R1, TP53, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	4.507E-07	5.709E-06	CAMK2B, GSK3B, SRC, AKT1, MAPK1, PIK3R1, PTK2
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	5.772E-07	6.451E-06	FLT3, MMP3, TP53, MPO, MMP9, MET, NFKB1, PTK2, IGF1R
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.375E-06	1.353E-05	CAMK2B, AKT1, MAPK1, PIK3R1, TP53, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	1.511E-06	1.367E-05	GSK3B, SRC, KDR, AKT1, MAPK1, PIK3R1, MET, PTK2, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	9.403E-07	9.926E-06	SRC, KDR, AKT1, MAPK1, PIK3R1, PTK2
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.424E-06	1.353E-05	CAMK2B, AKT1, MAPK1, PIK3R1, HIF1A, NFKB1, IGF1R
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.502E-06	1.917E-05	APP, CYP2C8, MAOA, ALOX5, ALOX15, MAPK1, ALOX12
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	2.322E-06	1.917E-05	AKT1, MAPK1, PIK3R1, TP53, MET, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	2.522E-06	1.917E-05	GSK3B, SRC, AKT1, MAPK1, PIK3R1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	3.546E-06	2.592E-05	GSK3B, SRC, AKT1, MAPK1, PIK3R1, TP53, HIF1A
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	3.966E-06	2.791E-05	CAMK2B, GSK3B, AKT1, MAPK1, PIK3R1, TP53, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	9.331E-06	5.372E-05	PLA2G1B, MAOA, GAA, ALOX15, AKR1B1, ALOX12, PYGL, CYP3A4, CYP19A1, HSD17B10, HSD11B1, CYP2C8, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, CD38, ALPI, XDH
09150 Organismal Systems	09151 Immune system	hsa04062	Chemokine signaling pathway	7.976E-06	5.051E-05	GSK3B, CXCR1, SRC, AKT1, MAPK1, PIK3R1, NFKB1, PTK2
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.322E-06	1.917E-05	SLCO1B1, CA2, SLCO1B3, NR1H4, CYP3A4, ABCG2
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	7.832E-06	5.051E-05	GSK3B, AKT1, MAPK1, PIK3R1, PPARA, TP53, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.480E-07	5.709E-06	CYP2C8, PLA2G1B, CYP1A2, ALOX15, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	9.067E-06	5.372E-05	GSK3B, CSNK2A1, AKT1, PIK3R1, TP53, NFKB1, TLR2
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.096E-05	5.951E-05	PARP1, LMNA, AKT1, MAPK1, PIK3R1, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	1.399E-05	7.185E-05	GSK3B, CSNK2A1, CDK1, AKT1, CD38, PIK3R1, TP53, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	1.046E-05	5.846E-05	PTPN1, GSK3B, AKT1, MAPK1, PIK3R1, PYGL, PTPRF
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.410E-06	3.671E-05	HSD11B1, CYP2C8, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.802E-05	8.561E-05	MMP2, PIM1, AKT1, MAPK1, PIK3R1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.517E-05	7.583E-05	CDK1, AKT1, MAPK1, PIK3R1, CDC25B, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.608E-05	7.831E-05	SRC, MMP2, AKT1, MAPK1, PIK3R1, MMP9
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	3.235E-05	1.336E-04	PLA2G1B, KDR, AKT1, MAPK1, PIK3R1, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	8.883E-06	5.372E-05	GSK3B, AKT1, MAPK1, PIK3R1, TP53
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	3.366E-05	1.361E-04	ABCC1, PIM1, CYP1B1, MAPK1, TP53, MMP9, MET, NFKB1, CDC25B
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	2.929E-05	1.237E-04	MMP3, AKT1, MAPK1, PIK3R1, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	1.283E-05	6.773E-05	ALK, AKT1, MAPK1, PIK3R1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	4.352E-05	1.722E-04	ALOX5, AKT1, MAPK1, PIK3R1, NFKB1, TLR2
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.248E-04	4.233E-04	POLB, SRC, CDK1, MAPK1, PIK3R1, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.037E-04	3.583E-04	CAMK2B, AKT1, MAPK1, PIK3R1, PPARA, NFKB1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.492E-04	4.972E-04	SRC, KDR, AKT1, MAPK1, PIK3R1, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	4.782E-05	1.747E-04	ABCC1, AKT1, MAPK1, PIK3R1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	2.877E-05	1.237E-04	AKT1, MAPK1, PIK3R1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	2.877E-05	1.237E-04	AKT1, MAPK1, PIK3R1, MET, HIF1A
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	2.119E-05	9.586E-05	GSK3B, AKT1, MAPK1, PIK3R1, TP53
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	4.692E-05	1.747E-04	AKT1, MAPK1, PIK3R1, TP53, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.119E-05	9.586E-05	CYP2C8, PLA2G1B, ALOX5, ALOX15, ALOX12
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	4.692E-05	1.747E-04	GSK3B, AKT1, MAPK1, PIK3R1, NFKB1
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.568E-04	5.135E-04	AKT1, PIK3R1, TP53, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	1.029E-04	3.583E-04	AKT1, PIK3R1, TP53, NFKB1, PTK2
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	2.517E-04	7.839E-04	GSK3B, AKT1, MAPK1, PIK3R1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	2.750E-04	8.427E-04	AKT1, MAPK1, PIK3R1, NFKB1, TLR2
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	3.404E-04	9.951E-04	CAMK2B, ACHE, AKT1, MAPK1, PIK3R1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.692E-05	1.747E-04	HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05152	Tuberculosis	4.127E-04	1.181E-03	CAMK2B, SRC, AKT1, MAPK1, NFKB1, TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	2.517E-04	7.839E-04	AKT1, MAPK1, PIK3R1, NFKB1, TLR2
09130 Environmental Information Processing	09132 Signal transduction	hsa04310	Wnt signaling pathway	1.043E-03	2.642E-03	CAMK2B, GSK3B, CSNK2A1, TP53, PPARD
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	1.371E-03	3.427E-03	GSK3B, AKT1, PIK3R1, PPARA, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	6.771E-04	1.787E-03	CAMK2B, GSK3B, MAOA, AKT1, DRD4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1.043E-03	2.642E-03	GSK3B, AKT1, MAPK1, PIK3R1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	1.674E-03	4.026E-03	PIM1, AKT1, STAT6, PIK3R1, PTPN2
09150 Organismal Systems	09152 Endocrine system	hsa04921	Oxytocin signaling pathway	1.674E-03	4.026E-03	CAMK2B, SRC, CD38, MAPK1, PIK3R1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	2.133E-03	4.911E-03	AKT1, MAPK1, PIK3R1, ADRA2C, ADRA2A
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	2.780E-03	6.071E-03	POLB, GSK3B, AKT1, PIK3R1, TP53, NFKB1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	2.189E-03	4.911E-03	BACE1, APP, GSK3B, MAPK1, HSD17B10
09160 Human Diseases	09167 Infectious diseases	hsa05164	Influenza A	2.613E-03	5.773E-03	GSK3B, AKT1, MAPK1, PIK3R1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05168	Herpes simplex infection	3.317E-03	7.162E-03	CSNK2A1, CDK1, TP53, NFKB1, TLR2
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1.968E-03	4.673E-03	CAMK2B, SRC, ALOX12, PIK3R1
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	1.498E-03	3.698E-03	CAMK2B, SRC, MMP2, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05146	Amoebiasis	2.119E-03	4.911E-03	PIK3R1, NFKB1, PTK2, TLR2
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	4.336E-03	9.153E-03	SRC, AKT1, MAPK1, PIK3R1
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	2.197E-03	4.911E-03	AKT1, MAPK1, PIK3R1, HIF1A
09150 Organismal Systems	09152 Endocrine system	hsa04922	Glucagon signaling pathway	2.197E-03	4.911E-03	CAMK2B, AKT1, PYGL, PPARA
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	4.463E-03	9.318E-03	CAMK2B, CDK1, MAPK1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2.380E-04	7.663E-04	FABP4, AKT1, PIK3R1, TSHR
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	3.851E-03	8.220E-03	MMP2, PIK3R1, MMP9, PTK2
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	4.593E-03	9.485E-03	GSK3B, CDK1, TP53, CDC25B
09160 Human Diseases	09167 Infectious diseases	hsa05100	Bacterial invasion of epithelial cells	8.438E-04	2.196E-03	SRC, PIK3R1, MET, PTK2
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	3.107E-04	9.225E-04	AKT1, MAPK1, PIK3R1, HIF1A
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5.021E-04	1.382E-03	CXCR1, SRC, MET, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5.308E-04	1.441E-03	CYP2C8, MAOA, CYP1A2, CYP3A4
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	4.226E-04	1.181E-03	RORC, STAT6, NFKB1, TLR2
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.226E-04	1.181E-03	CYP2C8, CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	6.327E-05	2.268E-04	MAOA, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	5.591E-04	1.496E-03	AKR1B10, GAA, AKR1B1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.859E-04	8.621E-04	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
NA: NA	Upper abdominal bloating	NA	ACHE;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR; MMP2;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; AKR1B1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
C00-D49: Neoplasms	CLL	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; HIF1A; MMP9; MMP2;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; APP;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1; APP;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1; MMP1;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE; APP;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; HIF1A; MMP9; MMP2; APP; CDC25B;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; AKR1B1;
NA: NA	Geographic retinal atrophy	NA	APP;
C00-D49: Neoplasms	Glioma	C71	KDR; APP;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; MMP2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases