CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	RECQL; HSD17B10;
Protein Phosphatase	CDC25B;
Protein Kinase	MAPK1;
Lyase	CA2; CA12; CA9;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	ALOX5;
Lysine demethylase	KDM4E;
Metallo protease	MMP1; MMP2; MMP9;
Transcription Factor	NFKB1;
Transferase	FUT7;
Unclassified	LMNA; MPEG1; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2D6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.783E-07	5.974E-03	CA12, CA2, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.799E-06	8.558E-03	CA12, CA2, CA9, MMP1, MMP2, MMP9, NR1H4, RORC

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.777E-07	5.288E-05	CA12, CA2, CA9
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	2.310E-04	4.293E-03	MAPK1, MMP9, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.690E-04	6.378E-03	LMNA, MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.692E-04	4.293E-03	MMP2, MAPK1, MMP9
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.436E-04	4.293E-03	CYP2D6, ALOX5, MAPK1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.082E-07	1.472E-05	MMP1, MMP2, MAPK1, MMP9
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.989E-05	2.715E-03	MMP1, MMP2, MAPK1, MMP9, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.795E-04	4.293E-03	MMP2, MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	2.822E-04	4.293E-03	MAPK1, MMP9, NFKB1, CDC25B
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	2.841E-04	4.293E-03	ALOX5, MAPK1, NFKB1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; MMP9; MAPK1; MMP2; CDC25B; CA9;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Ipomoea nil

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities