CMAUP Plant Collective Molecular Activities

Plant Name: Ptelea crenulata

Taxonomic Information:

Plant ID: NPO17009
Plant Latin Name: Ptelea crenulata
Taxonomy Genus: Ptelea
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Toll-like and Il-1 receptors	TLR2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.329E-10	7.250E-06	CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.660E-09	3.985E-05	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	9.929E-08	7.207E-04	CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.352E-07	1.280E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.823E-07	1.750E-03	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0006690; icosanoid metabolic process	2.997E-06	6.621E-03	CYP2C19, CYP2C9, TLR2
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.614E-06	6.621E-03	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.953E-06	6.621E-03	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	5.300E-06	7.625E-03	CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	5.603E-06	7.625E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.095E-05	1.037E-02	CYP2C19, CYP2C9, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.939E-03	4.180E-01	CYP2C19, CYP2C9, CYP3A4
CC	Unclassified;	GO:0106003; amyloid-beta complex	3.412E-03	6.041E-01	TLR2
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	4.354E-03	6.677E-01	CYP2C19, CYP2C9, CYP3A4, PPARA, TDP1, TLR2
CC	GO:0016020; membrane	GO:0031090; organelle membrane	4.614E-03	6.941E-01	CYP2C19, CYP2C9, CYP3A4, TLR2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases