Plant Name: Codiaeum variegatum
Taxonomic Information:
Plant ID: NPO16994
Plant Latin Name: Codiaeum variegatum
Taxonomy Genus: Codiaeum
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
138558
Plant-of-the-World-Online:
85073-3
Used in Medicines:
Country/Region:
Thailand; Indonesia; IndiaTraditional Medicine System:
Indian FolkGeographical Distribution:
Australia; Bangladesh; Cuba; Gambia; Philippines; Indonesia; India; New Caledonia; Papua New Guinea; Trinidad and Tobago; Mozambique; Vanuatu; Thailand; Dominican Republic; Fiji; Haiti
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FFAR1; FFAR4; | |
| TSHR; | |
| FAAH; TDP1; RECQL; TERT; ALOX15; ALDH1A1; HPGD; | |
| PPARD; PPARA; PPARG; | |
| NR1I2; | |
| PTGS1; | |
| TLR2; | |
| FABP3; FABP4; LMNA; FABP5; FABP2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | FAAH | Anandamide amidohydrolase | O00519 | CHEMBL2243 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Nuclear hormone receptor subfamily 1 group I | NR1I2 | Pregnane X receptor | O75469 | CHEMBL3401 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 1.286E-08 | 3.113E-05 | FABP2, FABP3, FABP4, FABP5 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 2.119E-07 | 2.307E-04 | NR1I2, PPARA, PPARD, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 4.519E-07 | 4.100E-04 | NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 7.568E-07 | 6.103E-04 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 1.547E-06 | 1.087E-03 | FABP3, FFAR1, PPARG, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 6.598E-06 | 3.265E-03 | FFAR4, PPARA, PPARD, PPARG |
| BP | GO:0008283; cell proliferation | GO:0048660; regulation of smooth muscle cell proliferation | 1.009E-05 | 4.484E-03 | HPGD, PPARD, PPARG, TERT |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 1.073E-05 | 4.672E-03 | NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 1.124E-05 | 4.772E-03 | PPARA, PPARG |
| BP | GO:0050896; response to stimulus | GO:0032868; response to insulin | 1.397E-05 | 5.635E-03 | FABP3, PPARA, PPARG, TLR2 |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 1.684E-05 | 6.216E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 1.684E-05 | 6.216E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 1.684E-05 | 6.216E-03 | ALOX15, HPGD |
| MF | Unclassified; | GO:0004872; receptor activity | 1.672E-05 | 6.216E-03 | FFAR1, FFAR4, HPGD, NR1I2, PPARA, PPARD, PPARG, TLR2, TSHR |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 1.684E-05 | 6.216E-03 | FABP3, PPARG |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 2.431E-05 | 8.679E-03 | NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 2.651E-05 | 9.162E-03 | ALOX15, FAAH, PTGS1 |
| MF | GO:0060089; molecular transducer activity | GO:0004955; prostaglandin receptor activity | 5.039E-05 | 1.590E-02 | HPGD, PPARG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 4.760E-13 | 2.380E-11 | FABP2, FABP3, FABP4, FABP5, PPARG, PPARA, PPARD |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 2.668E-05 | 6.671E-04 | FABP4, TSHR, PTGS1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.912E-03 | 3.186E-02 | ALOX15, PTGS1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 6.089E-03 | 7.611E-02 | ALOX15, PTGS1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 1.827E-02 | 1.522E-01 | PPARA, TSHR |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 1.512E-02 | 1.512E-01 | HPGD, PPARG |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 7.493E-02 | 1.738E-01 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 8.367E-02 | 1.738E-01 | LMNA |
| 09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 9.424E-02 | 1.738E-01 | PPARG |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 9.041E-02 | 1.738E-01 | LMNA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
