CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1; HSD17B10; ALDH1A1; AKR1B10; AKR1B1;
Lyase	CA2; CA12; CA14; CA7;
Nuclear hormone receptor subfamily 2 group B	RXRA;
Lysine demethylase	KDM4E;
Metallo protease	MMP1; MMP2; MMP9;
Serine protease	F2;
Transcription Factor	NFKB1; TP53;
Transferase	FUT7;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226

Showing 1 to 10 of 20 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.105E-07	1.203E-03	CA12, CA14, CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.132E-09	2.465E-05	CA12, CA14, CA2, CA7
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.638E-07	4.158E-03	CA12, CA2, CA7, MMP1, MMP2, MMP9, RXRA, TP53

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.716E-09	1.682E-07	CA12, CA2, CA7, CA14
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5.864E-04	4.789E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	4.064E-04	3.983E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4.628E-04	4.123E-03	AKR1B10, AKR1B1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.507E-04	3.983E-03	LMNA, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	7.190E-08	3.523E-06	MMP1, MMP2, MMP9, TP53
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.804E-06	5.893E-05	RXRA, MMP1, MMP2, TP53, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.747E-05	6.729E-04	RXRA, TP53, MMP9, NFKB1
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	8.300E-05	1.627E-03	RXRA, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	3.017E-04	3.983E-03	RXRA, TP53, NFKB1

Showing 1 to 10 of 14 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
C00-D49: Neoplasms	Cutaneous T-cell lymphoma	C84.0, C84.1	RXRA;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1; TP53;

Showing 1 to 10 of 59 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cichorium glandulosum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities