CMAUP Plant Collective Molecular Activities

Plant Name: Helianthus maximiliani

Taxonomic Information:

Plant ID: NPO16913
Plant Latin Name: Helianthus maximiliani
Taxonomy Genus: Helianthus
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 73297
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Miscellaneous ion channel	BCL2;
Enzyme_unclassified	P4HB; AKR1B1; UBE2N;
Aspartic protease	BACE1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	P4HB	Protein disulfide-isomerase	P07237	CHEMBL5422
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	UBE2N	Ubiquitin-conjugating enzyme E2 N	P61088	CHEMBL6089
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0023052; signaling	GO:0023051; regulation of signaling	3.086E-05	2.529E-01	AKR1B1, BACE1, BCL2, CYP19A1, P4HB, UBE2N
BP	GO:0032501; multicellular organismal process	GO:0035265; organ growth	3.484E-05	2.529E-01	BCL2, CYP19A1
BP	GO:0050896; response to stimulus	GO:0006979; response to oxidative stress	1.067E-04	3.442E-01	AKR1B1, BCL2, P4HB
BP	GO:0008152; metabolic process	GO:0042446; hormone biosynthetic process	1.460E-04	3.442E-01	AKR1B1, CYP19A1
BP	GO:0008152; metabolic process	GO:0006694; steroid biosynthetic process	6.225E-04	3.442E-01	AKR1B1, CYP19A1
BP	GO:0009987; cellular process	GO:0071453; cellular response to oxygen levels	6.323E-04	3.442E-01	BCL2, P4HB
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	4.578E-04	3.442E-01	AKR1B1, CYP19A1
MF	GO:0003824; catalytic activity	GO:0016705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	9.396E-04	3.988E-01	CYP19A1, P4HB
MF	GO:0005488; binding	GO:0051434; BH3 domain binding	1.552E-03	4.761E-01	BCL2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09120 Genetic Information Processing	09123 Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	1.041E-03	3.228E-02	BCL2, P4HB
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.491E-02	6.108E-02	CYP19A1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	8.967E-03	6.108E-02	AKR1B1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	1.520E-02	6.108E-02	BCL2
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	3.285E-02	6.108E-02	BCL2
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	2.758E-02	6.108E-02	BCL2
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	3.051E-02	6.108E-02	BCL2
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	3.489E-02	6.108E-02	BCL2
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	3.547E-02	6.108E-02	BCL2
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	3.547E-02	6.108E-02	BCL2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	BCL2;
C00-D49: Neoplasms	Multiple myeloma	C90	BCL2;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	BCL2;
C00-D49: Neoplasms	Breast cancer	C50	BCL2;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
C00-D49: Neoplasms	Prostate cancer	C61	BCL2;
C00-D49: Neoplasms	Leukemia	C90-C95	BCL2;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases