CMAUP Plant Collective Molecular Activities

Plant Name: Elsholtzia bodinieri

Taxonomic Information:

Plant ID: NPO16841
Plant Latin Name: Elsholtzia bodinieri
Taxonomy Genus: Elsholtzia
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 1874228
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	PRKCB; PRKCE; PRKCD; PRKCG; PRKCA;
Lyase	CA7; CA4;
Enzyme_unclassified	CBR1;
SLC superfamily of solute carriers	SLCO1B1;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Protein Kinase	PRKCB	Protein kinase C beta	P05771	CHEMBL3045
Protein Kinase	PRKCE	Protein kinase C epsilon	Q02156	CHEMBL3582
Protein Kinase	PRKCD	Protein kinase C delta	Q05655	CHEMBL2996
Protein Kinase	PRKCG	Protein kinase C gamma	P05129	CHEMBL2938
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.930E-11	3.578E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.610E-10	8.765E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.398E-09	4.123E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.383E-09	4.123E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH
MF	GO:0003824; catalytic activity	GO:0004698; calcium-dependent protein kinase C activity	1.515E-09	4.123E-06	PRKCA, PRKCB, PRKCG
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.067E-09	5.000E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0030168; platelet activation	1.568E-08	2.277E-05	PRKCA, PRKCB, PRKCD, PRKCE, PRKCG
MF	GO:0005488; binding	GO:0020037; heme binding	3.364E-08	4.578E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0018105; peptidyl-serine phosphorylation	1.199E-07	1.136E-04	PRKCA, PRKCB, PRKCD, PRKCE, PRKCG
BP	GO:0008152; metabolic process	GO:0035408; histone H3-T6 phosphorylation	5.629E-07	4.226E-04	PRKCA, PRKCB
MF	GO:0003824; catalytic activity	GO:0035403; histone kinase activity (H3-T6 specific)	5.629E-07	4.226E-04	PRKCA, PRKCB
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	6.647E-07	4.825E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	1.329E-06	7.617E-04	CYP19A1, CYP1A1, CYP1B1, PRKCA, PRKCE, SLCO1B1
MF	GO:0003824; catalytic activity	GO:0004699; calcium-independent protein kinase C activity	1.688E-06	9.188E-04	PRKCD, PRKCE
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	2.126E-06	1.095E-03	CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.235E-06	1.106E-03	CYP19A1, CYP1A1, CYP2C19
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.374E-06	1.633E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.428E-06	3.905E-03	CYP1A2, CYP2C19
BP	GO:0009987; cellular process	GO:0034351; negative regulation of glial cell apoptotic process	1.572E-05	6.338E-03	PRKCA, PRKCD
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.572E-05	6.338E-03	CYP1A1, CYP1A2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7.360E-09	2.110E-07	PRKCG, PRKCB, PRKCE, PRKCD, PRKCA
09150 Organismal Systems	09151 Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5.644E-09	2.110E-07	PRKCG, PRKCB, PRKCE, PRKCD, PRKCA
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.977E-09	2.110E-07	CBR1, CYP1A2, CYP1A1, CYP1B1, CYP2C19
09150 Organismal Systems	09153 Circulatory system	hsa04270	Vascular smooth muscle contraction	2.047E-08	4.400E-07	PRKCG, PRKCB, PRKCE, PRKCD, PRKCA
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04530	Tight junction	4.284E-08	7.368E-07	PRKCG, PRKCB, PRKCE, PRKCD, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04925	Aldosterone synthesis and secretion	3.294E-07	3.541E-06	PRKCG, PRKCB, PRKCE, PRKCA
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.485E-08	1.216E-06	CYP1A2, CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8.012E-07	7.656E-06	PRKCB, PRKCE, PRKCD, PRKCA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.162E-07	2.657E-06	CBR1, CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.213E-06	1.043E-05	PRKCG, PRKCB, PRKCA, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.856E-06	1.330E-05	PRKCG, PRKCB, PRKCE, CYP1B1, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.599E-06	1.250E-05	PRKCG, PRKCB, PRKCE, PRKCA
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	9.238E-06	4.181E-05	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09167 Infectious diseases	hsa05143	African trypanosomiasis	2.202E-06	1.457E-05	PRKCG, PRKCB, PRKCA
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.316E-06	1.901E-05	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09155 Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3.069E-06	1.885E-05	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09155 Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5.426E-06	2.745E-05	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	6.549E-06	3.129E-05	CYP1A1, CYP1B1, CYP19A1
09130 Environmental Information Processing	09132 Signal transduction	hsa04150	mTOR signaling pathway	1.138E-05	4.662E-05	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	1.450E-05	5.421E-05	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	1.197E-05	4.678E-05	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	1.138E-05	4.662E-05	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	1.589E-05	5.465E-05	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	2.143E-05	6.825E-05	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	1.518E-05	5.440E-05	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04911	Insulin secretion	3.249E-05	9.979E-05	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.892E-05	6.258E-05	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	3.483E-05	1.000E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	3.985E-05	1.008E-04	PRKCB, PRKCD, PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04727	GABAergic synapse	3.605E-05	1.000E-04	PRKCG, PRKCB, PRKCA
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	3.605E-05	1.000E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09154 Digestive system	hsa04970	Salivary secretion	3.729E-05	1.002E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09159 Environmental adaptation	hsa04713	Circadian entrainment	4.532E-05	1.114E-04	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09164 Substance dependence	hsa05032	Morphine addiction	3.985E-05	1.008E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04916	Melanogenesis	5.283E-05	1.142E-04	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04070	Phosphatidylinositol signaling system	4.974E-05	1.142E-04	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09167 Infectious diseases	hsa05146	Amoebiasis	5.283E-05	1.142E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	5.442E-05	1.142E-04	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	5.442E-05	1.142E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	7.211E-05	1.378E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	4.676E-05	1.117E-04	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	5.770E-05	1.182E-04	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	6.831E-05	1.366E-04	PRKCB, PRKCE, PRKCD
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	7.807E-05	1.460E-04	PRKCG, PRKCB, PRKCA
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.720E-04	2.790E-04	CBR1, CYP1A2, CYP1A1, CYP2C19, CYP19A1, XDH
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	8.650E-05	1.550E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	1.127E-04	1.978E-04	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.626E-04	2.689E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09151 Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1.290E-04	2.218E-04	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04310	Wnt signaling pathway	1.498E-04	2.526E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04921	Oxytocin signaling pathway	2.053E-04	3.269E-04	PRKCG, PRKCB, PRKCA
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	8.650E-05	1.550E-04	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	3.012E-04	4.626E-04	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.284E-04	6.353E-04	PRKCG, PRKCB, PRKCA
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	4.223E-04	6.353E-04	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	4.797E-04	6.992E-04	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	5.936E-04	8.368E-04	PRKCG, PRKCB, PRKCA
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	8.321E-04	1.154E-03	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.957E-03	3.853E-03	PRKCG, PRKCB, PRKCA
09160 Human Diseases	09167 Infectious diseases	hsa05164	Influenza A	7.417E-03	9.520E-03	PRKCB, PRKCA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.196E-03	1.583E-03	CYP1A2, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.063E-03	1.428E-03	CYP1A2, CYP1A1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.673E-04	1.321E-03	CBR1, CYP2C19
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04930	Type II diabetes mellitus	5.805E-04	8.321E-04	PRKCE, PRKCD
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.107E-04	3.294E-04	CYP1A2, CYP2C19
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	5.243E-06	2.745E-05	CYP1A2, XDH
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.094E-05	1.378E-04	CA4, CA7

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
I00-I99: Diseases of the circulatory system	Heart failure	I50	XDH;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Renal transplantation	D89.8	PRKCB;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Central nervous system tumors	NA	PRKCB;
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	PRKCE;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH;
NA: NA	Reperfusion injury and heart attacks	NA	PRKCD;
I00-I99: Diseases of the circulatory system	Ischemic reperfusion injury	I00-I99	PRKCE;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Brain cancer	C71, D33	PRKCB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH;
C00-D49: Neoplasms	Lymphoma	C81-C86	PRKCB;
I00-I99: Diseases of the circulatory system	Acute myocardial infarction	I21-I22	PRKCD;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	PRKCB;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	PRKCB;
J00-J99: Diseases of the respiratory system	Asthma	J45	CBR1;
C00-D49: Neoplasms	Cancer	C00-C96	PRKCB;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	XDH;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases