CMAUP Plant Collective Molecular Activities

Plant Name: Physalis angulata

Taxonomic Information:

Plant ID: NPO1680
Plant Latin Name: Physalis angulata
Taxonomy Genus: Physalis
Taxonomy Family: Solanaceae

Plant External Links:

NCBI TaxonomyDB: 113208
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Brazil; Ghana; Indonesia; India; Kenya; Bolivia

Traditional Medicine System:

Medicinal Functions:

Diuretic; Expectorant; Febrifuge

Geographical Distribution:

Brazil; Ghana; Indonesia; India; Kenya; Bolivia

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Metallo protease	MMP9; MMP2; MMP12;
Unclassified	GLI1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Unclassified	GLI1	Zinc finger protein GLI1	P08151	CHEMBL5461

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	1.451E-07	1.480E-03	MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	2.626E-07	1.480E-03	MMP12, MMP2, MMP9
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	3.398E-07	1.480E-03	MMP12, MMP2, MMP9
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	6.400E-07	2.323E-03	MMP12, MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0004222; metalloendopeptidase activity	8.188E-07	2.547E-03	MMP12, MMP2, MMP9
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	4.418E-06	1.069E-02	GLI1, MMP12, MMP2, MMP9
BP	GO:0008283; cell proliferation	GO:1904707; positive regulation of vascular smooth muscle cell proliferation	7.420E-06	1.616E-02	MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0004252; serine-type endopeptidase activity	8.285E-06	1.640E-02	MMP12, MMP2, MMP9
CC	GO:0044421; extracellular region part	GO:0005578; proteinaceous extracellular matrix	1.193E-05	1.787E-02	MMP12, MMP2, MMP9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.878E-04	1.959E-01	MMP12, MMP2, MMP9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	3.060E-05	2.142E-04	MMP2, GLI1, MMP9
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.454E-05	2.142E-04	MMP2, MMP9
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.446E-04	6.748E-04	MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	6.069E-04	1.699E-03	MMP2, MMP9
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	2.055E-04	7.193E-04	MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05217	Basal cell carcinoma	1.096E-02	2.191E-02	GLI1
09130 Environmental Information Processing	09132 Signal transduction	hsa04340	Hedgehog signaling pathway	9.963E-03	2.191E-02	GLI1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.005E-02	3.055E-02	MMP2
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	1.808E-02	3.055E-02	MMP2
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	2.182E-02	3.055E-02	MMP9

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
C00-D49: Neoplasms	Cancer	C00-C96	MMP9;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases