CMAUP Plant Collective Molecular Activities

Plant Name: Knoxia valerianoides

Taxonomic Information:

Plant ID: NPO16765
Plant Latin Name: Knoxia valerianoides
Taxonomy Genus: Knoxia
Taxonomy Family: Rubiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; CDC25B; PTPRF;
Enzyme_unclassified	PLA2G1B; RECQL; HSD11B1; AKR1B10; POLB;
Miscellaneous ion channel	BCL2;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Unclassified	MCL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.334E-08	8.444E-05	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0019740; nitrogen utilization	GO:0006808; regulation of nitrogen utilization	1.929E-06	4.968E-03	BCL2, NR1H4
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.929E-06	4.968E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.929E-06	4.968E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	3.856E-06	8.396E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	8.394E-06	1.269E-02	NR1H4, PTPN1, PTPN2
MF	GO:0005488; binding	GO:0051434; BH3 domain binding	6.423E-06	1.269E-02	BCL2, MCL1
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	1.796E-05	2.284E-02	ACP1, PTPN2
MF	GO:0005488; binding	GO:0032052; bile acid binding	2.308E-05	2.284E-02	NR1H4, PLA2G1B

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.630E-05	1.499E-03	PTPN1, ACP1, PTPRF
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	2.512E-04	7.159E-03	BCL2, PTPN2, MCL1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.573E-03	2.989E-02	BCL2, CDC25B, MCL1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	3.360E-03	4.788E-02	PTPN1, PTPRF
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	5.475E-03	5.201E-02	BCL2, MCL1
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	5.399E-03	5.201E-02	PTPN1, PTPRF
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2.842E-02	1.200E-01	AKR1B10
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4.389E-02	1.200E-01	TSHR
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4.542E-02	1.200E-01	HSD11B1
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	5.533E-02	1.200E-01	TSHR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases