CMAUP Plant Collective Molecular Activities

Plant Name: Pandanus tectorius

Taxonomic Information:

Plant ID: NPO16710
Plant Latin Name: Pandanus tectorius
Taxonomy Genus: Pandanus
Taxonomy Family: Pandanaceae

Plant External Links:

NCBI TaxonomyDB: 4726
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Thailand; India

Traditional Medicine System:

Geographical Distribution:

Thailand; India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Nuclear hormone receptor subfamily 3 group A	ESR1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0009755; hormone-mediated signaling pathway	2.216E-04	7.119E-01	ESR1, TSHR
BP	GO:0009987; cellular process	GO:0038194; thyroid-stimulating hormone signaling pathway	3.106E-04	7.119E-01	TSHR
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	3.106E-04	7.119E-01	TSHR
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	3.106E-04	7.119E-01	ESR1
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	6.212E-04	7.119E-01	ESR1
MF	GO:0098772; molecular function regulator	GO:0030235; nitric-oxide synthase regulator activity	1.087E-03	8.452E-01	ESR1
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	2.861E-02	1.000E+00	TSHR
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	4.918E-02	1.000E+00	TSHR
MF	Unclassified;	GO:0004872; receptor activity	1.839E-02	1.000E+00	ESR1, TSHR
MF	GO:0060089; molecular transducer activity	GO:0008528; G-protein coupled peptide receptor activity	2.021E-02	1.000E+00	TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09155 Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7.034E-03	2.299E-02	ESR1
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	7.929E-03	2.299E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8.377E-03	2.299E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.076E-02	2.299E-02	ESR1
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.061E-02	2.299E-02	TSHR
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.106E-02	2.299E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	1.240E-02	2.299E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	1.344E-02	2.299E-02	LMNA
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.478E-02	2.299E-02	ESR1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.760E-02	2.464E-02	ESR1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases