CMAUP Plant Collective Molecular Activities

Plant Name: Peucedanum japonicum

Taxonomic Information:

Plant ID: NPO16675
Plant Latin Name: Peucedanum japonicum
Taxonomy Genus: Peucedanum
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 49563
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Antiarthritic; Cytotoxic

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A;
Peptide receptor (family A GPCR)	NMUR2; TSHR;
Hydrolase	GAA; ACHE;
Protein Kinase	MAPK1;
Transcription Factor	NFKB1;
Enzyme_unclassified	POLB;
Methyl-lysine/arginine binding protein	L3MBTL1;
Unclassified	NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A13; CYP3A4; CYP1A2; CYP2A6; CYP2C19; CYP2C9; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.018E-13	2.477E-09	CYP1A2, CYP2A6, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.412E-13	2.477E-09	CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.054E-12	8.947E-09	CYP1A2, CYP2A13, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.715E-12	2.100E-08	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	1.424E-11	3.445E-08	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	6.912E-11	1.158E-07	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.600E-10	3.774E-07	CYP1A2, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	6.484E-10	7.843E-07	CYP1A2, CYP2A13, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	1.247E-09	1.357E-06	CYP2A13, CYP2A6, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.450E-09	1.503E-06	CYP1A2, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, NPC1
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.716E-09	2.572E-06	CYP1A2, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.622E-09	4.025E-06	CYP1A2, CYP2A13, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	2.373E-08	1.845E-05	CYP2A13, CYP2A6, CYP2D6
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.120E-08	5.704E-05	CYP1A2, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	8.202E-07	4.252E-04	CYP2A13, CYP2A6
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	2.459E-06	1.139E-03	CYP2D6, CYP3A4
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	2.459E-06	1.139E-03	ADRA2A, ADRA2C
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	4.916E-06	2.141E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	4.916E-06	2.141E-03	ADRA2A, ADRA2C
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.097E-05	4.424E-03	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0046686; response to cadmium ion	1.826E-05	6.740E-03	CYP1A2, MAPK1, NPC1
BP	GO:0009987; cellular process	GO:0010700; negative regulation of norepinephrine secretion	2.289E-05	8.171E-03	ADRA2A, ADRA2C
MF	GO:0005488; binding	GO:0051379; epinephrine binding	2.289E-05	8.171E-03	ADRA2A, ADRA2C
BP	GO:0032501; multicellular organismal process	GO:0006940; regulation of smooth muscle contraction	2.863E-05	9.894E-03	ADRA2A, ADRA2C, NMUR2
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.294E-15	4.995E-11	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.425E-11	2.148E-09	CYP2C9, CYP2A6, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.437E-11	2.148E-09	CYP2C9, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	7.037E-11	2.932E-09	CYP2C9, CYP2A6, CYP2A13, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.075E-08	3.360E-07	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.004E-07	7.510E-06	CYP2C9, CYP2A6, CYP1A2, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.684E-06	5.592E-05	CYP2C9, CYP2D6, MAPK1, CYP2C19
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9.454E-05	1.477E-03	NMUR2, ADRA2C, ADRA2A, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	4.255E-04	5.910E-03	MAPK1, ADRA2C, ADRA2A
Unclassified	Unclassified	hsa01100	Metabolic pathways	5.430E-04	6.788E-03	CYP2C9, CYP2A6, GAA, CYP1A2, CYP2C19, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	7.092E-04	7.437E-03	MAPK1, NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	7.730E-04	7.437E-03	POLB, MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.186E-03	9.589E-03	MAPK1, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7.735E-04	7.437E-03	CYP2A6, CYP3A4
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.186E-03	9.589E-03	MAPK1, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.227E-03	9.589E-03	CYP1A2, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	7.638E-06	1.364E-04	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases