Plant Name: Plumbago indica
Taxonomic Information:
Plant ID: NPO16662
Plant Latin Name: Plumbago indica
Taxonomy Genus: Plumbago
Taxonomy Family: Plumbaginaceae
Plant External Links:
NCBI TaxonomyDB:
122308
Plant-of-the-World-Online:
687077-1
Used in Medicines:
Country/Region:
Thailand; China; IndiaTraditional Medicine System:
Indian Folk; TCM; Unani; Ayurveda; SiddhaGeographical Distribution:
Bangladesh; India; Cambodia; Trinidad and Tobago; China; Peru; Thailand
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| MAPK1; | |
| ALOX15; | |
| KDM4E; | |
| TP53; | |
| EP300; | |
| ABCG2; | |
| MAPT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Bromodomain | EP300 | Histone acetyltransferase p300 | Q09472 | CHEMBL3784 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 2.892E-06 | 3.149E-02 | CYP2C19, CYP2C9 |
| BP | GO:0009987; cellular process | GO:1900034; regulation of cellular response to heat | 5.229E-06 | 3.458E-02 | EP300, MAPK1, MAPT |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 8.667E-06 | 3.458E-02 | CYP2C19, CYP2C9 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.271E-05 | 3.458E-02 | CYP2C19, CYP2C9 |
| MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 2.615E-05 | 5.694E-02 | CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 4.034E-05 | 7.456E-02 | CYP2C19, CYP2C9 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 4.517E-05 | 7.562E-02 | ALOX15, CYP2C19, CYP2C9 |
| MF | GO:0005488; binding | GO:0019902; phosphatase binding | 4.862E-05 | 7.562E-02 | MAPK1, MAPT, TP53 |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 7.249E-05 | 9.866E-02 | MAPT, TP53 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 1.074E-04 | 1.300E-01 | CYP2C19, CYP2C9 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.891E-04 | 1.715E-01 | CYP2C19, CYP2C9 |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 4.200E-04 | 1.812E-01 | MAPK1, MAPT |
| MF | GO:0003824; catalytic activity | GO:0016491; oxidoreductase activity | 2.190E-04 | 1.812E-01 | ALOX15, CYP2C19, CYP2C9, KDM4E |
| MF | GO:0005488; binding | GO:0003684; damaged DNA binding | 4.200E-04 | 1.812E-01 | EP300, TP53 |
| CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 4.099E-03 | 3.783E-01 | ABCG2, CYP2C19, CYP2C9, EP300, KDM4E, MAPK1, MAPT, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.149E-07 | 1.270E-05 | CYP2C9, ALOX15, MAPK1, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.289E-07 | 1.270E-05 | CYP2C9, ALOX15, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 2.352E-06 | 8.701E-05 | CYP2C9, ALOX15, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 7.018E-06 | 1.948E-04 | EP300, MAPK1, TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.639E-05 | 3.638E-04 | EP300, MAPK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 3.100E-05 | 5.735E-04 | EP300, MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 8.518E-05 | 1.182E-03 | EP300, MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 1.626E-04 | 1.805E-03 | MAPK1, MAPT, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 7.262E-05 | 1.152E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 2.548E-04 | 2.290E-03 | EP300, MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 1.463E-04 | 1.804E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05213 | Endometrial cancer | 2.359E-04 | 2.290E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 2.737E-04 | 2.290E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 3.690E-04 | 2.290E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 3.357E-04 | 2.290E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 3.804E-04 | 2.290E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 5.965E-04 | 2.628E-03 | EP300, MAPK1, TP53 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04720 | Long-term potentiation | 3.804E-04 | 2.290E-03 | EP300, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05211 | Renal cell carcinoma | 3.804E-04 | 2.290E-03 | EP300, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 3.920E-04 | 2.290E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 4.402E-04 | 2.307E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 4.653E-04 | 2.307E-03 | MAPK1, TP53 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 4.157E-04 | 2.307E-03 | CYP2C9, CYP2C19 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 4.781E-04 | 2.307E-03 | EP300, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04916 | Melanogenesis | 8.709E-04 | 3.580E-03 | EP300, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04350 | TGF-beta signaling pathway | 6.156E-04 | 2.628E-03 | EP300, MAPK1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 9.235E-04 | 3.661E-03 | EP300, MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 1.250E-03 | 4.626E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 5.867E-04 | 2.628E-03 | CYP2C9, CYP2C19 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.696E-03 | 5.531E-03 | MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 1.250E-03 | 4.626E-03 | MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 1.533E-03 | 5.155E-03 | EP300, MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 1.533E-03 | 5.155E-03 | MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04310 | Wnt signaling pathway | 1.744E-03 | 5.531E-03 | EP300, TP53 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04110 | Cell cycle | 1.334E-03 | 4.777E-03 | EP300, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05164 | Influenza A | 2.632E-03 | 7.896E-03 | EP300, MAPK1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.429E-03 | 7.490E-03 | MAPK1, MAPT |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05016 | Huntington's disease | 3.190E-03 | 8.851E-03 | EP300, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05152 | Tuberculosis | 2.721E-03 | 7.950E-03 | EP300, MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05169 | Epstein-Barr virus infection | 3.488E-03 | 9.090E-03 | EP300, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 3.521E-03 | 9.090E-03 | MAPK1, TP53 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 3.387E-03 | 9.090E-03 | EP300, MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05168 | Herpes simplex infection | 2.936E-03 | 8.355E-03 | EP300, TP53 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
