Plant Name: Diospyros maritima
Taxonomic Information:
Plant ID: NPO16657
Plant Latin Name: Diospyros maritima
Taxonomy Genus: Diospyros
Taxonomy Family: Ebenaceae
Plant External Links:
NCBI TaxonomyDB:
413758
Plant-of-the-World-Online:
322671-1
Used in Medicines:
Country/Region:
ChinaTraditional Medicine System:
TCMGeographical Distribution:
Philippines; Australia; China; Taiwan; Indonesia
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| MAPK1; | |
| CA12; CA9; CA7; | |
| PPARA; PPARD; | |
| KDM4E; | |
| GFER; HSD17B10; ALOX15; ALDH1A1; | |
| CASP1; CASP7; | |
| TLR2; | |
| TP53; | |
| EP300; | |
| LMNA; FABP3; FABP5; FABP2; FABP4; MAPT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP1A2; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Bromodomain | EP300 | Histone acetyltransferase p300 | Q09472 | CHEMBL3784 |
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0001666; response to hypoxia | 1.467E-08 | 8.275E-05 | CASP1, EP300, LMNA, PPARA, PPARD, TLR2, TP53 |
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 1.900E-08 | 8.275E-05 | FABP2, FABP3, FABP4, FABP5 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 6.647E-07 | 9.751E-04 | CA12, CA7, CA9 |
| BP | GO:0050896; response to stimulus | GO:0042060; wound healing | 1.951E-06 | 1.931E-03 | ALOX15, PPARA, PPARD, TP53 |
| BP | GO:0009987; cellular process | GO:0006915; apoptotic process | 5.964E-06 | 4.189E-03 | CASP1, CASP7, EP300, MAPK1, PPARD, TLR2, TP53 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.026E-05 | 6.385E-03 | CA12, CA7, CA9 |
| BP | GO:0050896; response to stimulus | GO:0033993; response to lipid | 1.437E-05 | 8.237E-03 | CA9, CASP1, CYP1A2, FABP3, PPARD, TLR2, TP53 |
| BP | GO:0050896; response to stimulus | GO:0014070; response to organic cyclic compound | 1.503E-05 | 8.393E-03 | CA9, CASP1, CASP7, CYP1A2, MAPK1, TLR2, TP53 |
| MF | GO:0005488; binding | GO:0097371; MDM2/MDM4 family protein binding | 2.838E-05 | 1.343E-02 | PPARA, TP53 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 3.094E-05 | 1.394E-02 | CA12, CA7, CA9, EP300, PPARA, PPARD, TP53 |
| MF | GO:0005488; binding | GO:0019902; phosphatase binding | 3.911E-05 | 1.607E-02 | MAPK1, MAPT, PPARA, TP53 |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 5.533E-05 | 2.042E-02 | ALDH1A1, ALOX15, CA7, CASP1, CASP7, EP300, FABP2, FABP3, FABP4, FABP5, GFER, LMNA, MAPK1, MAPT, TP53 |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 7.411E-05 | 2.561E-02 | FABP3, PPARD |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.301E-10 | 1.692E-08 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.837E-05 | 7.040E-04 | CASP7, LMNA, MAPK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 2.166E-05 | 7.040E-04 | EP300, MAPK1, TP53, TLR2 |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 8.939E-07 | 5.810E-05 | CA12, CA7, CA9 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 3.352E-05 | 8.136E-04 | CASP7, CASP1, TLR2 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 3.755E-05 | 8.136E-04 | CASP7, MAPK1, MAPT, HSD17B10 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 1.414E-04 | 2.298E-03 | EP300, MAPK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 8.499E-05 | 1.578E-03 | CASP7, CASP1, MAPK1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 3.253E-04 | 4.699E-03 | EP300, MAPK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 4.619E-04 | 5.460E-03 | MAPK1, PPARA, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.004E-03 | 8.234E-03 | EP300, MAPK1, TP53, PPARD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04310 | Wnt signaling pathway | 5.592E-04 | 5.592E-03 | EP300, TP53, PPARD |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05164 | Influenza A | 1.025E-03 | 8.234E-03 | CASP1, EP300, MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05152 | Tuberculosis | 1.077E-03 | 8.234E-03 | EP300, MAPK1, TLR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 1.571E-03 | 9.156E-03 | MAPK1, TP53, TLR2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 1.484E-03 | 9.156E-03 | EP300, MAPK1, PPARA |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 5.040E-04 | 5.460E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 1.616E-03 | 9.156E-03 | EP300, MAPK1, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05168 | Herpes simplex infection | 1.203E-03 | 8.691E-03 | EP300, TP53, TLR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 1.009E-03 | 8.234E-03 | MAPK1, TP53 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 5.040E-04 | 5.460E-03 | CYP1A2, ALOX15 |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 1.876E-03 | 9.714E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05213 | Endometrial cancer | 1.620E-03 | 9.156E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.943E-03 | 9.714E-03 | MAPK1, PPARD |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 1.559E-03 | 9.156E-03 | CASP1, TP53 |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 1.943E-03 | 9.714E-03 | CASP1, MAPK1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Breast cancer | C50 | CA9; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9; |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9; |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
