Plant Name: Polygala ruwenzoriensis
Taxonomic Information:
Plant ID: NPO16557
Plant Latin Name: Polygala ruwenzoriensis
Taxonomy Genus: Polygala
Taxonomy Family: Polygalaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| NR1H4; | |
| MAPT; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 9.649E-08 | 1.050E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.449E-03 | 5.547E-01 | NR1H4 |
| CC | GO:0043226; organelle | GO:0016607; nuclear speck | 2.129E-03 | 5.795E-01 | LMNA, MAPT |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 2.276E-03 | 6.110E-01 | MAPT |
| MF | GO:0005488; binding | GO:0046965; retinoid X receptor binding | 3.103E-03 | 7.188E-01 | NR1H4 |
| CC | GO:0044464; cell part | GO:0030673; axolemma | 3.309E-03 | 7.279E-01 | MAPT |
| MF | GO:0005488; binding | GO:0034185; apolipoprotein binding | 3.309E-03 | 7.279E-01 | MAPT |
| MF | GO:0005488; binding | GO:0016922; ligand-dependent nuclear receptor binding | 4.342E-03 | 8.012E-01 | NR1H4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.472E-02 | 3.129E-02 | LMNA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.413E-02 | 3.129E-02 | NR1H4 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.650E-02 | 3.129E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.788E-02 | 3.129E-02 | LMNA |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.771E-02 | 3.871E-02 | LMNA |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 3.318E-02 | 3.871E-02 | MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 5.004E-02 | 5.004E-02 | MAPT |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
