CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Transcription Factor	STAT3;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Transcription Factor	STAT3	Signal transducer and activator of transcription 3	P40763	CHEMBL4026

Showing 1 to 3 of 3 entries

Previous1Next

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0060397; JAK-STAT cascade involved in growth hormone signaling pathway	1.688E-06	3.675E-02	PTPN1, STAT3
BP	GO:0008152; metabolic process	GO:0042326; negative regulation of phosphorylation	1.360E-05	7.401E-02	PTPN1, STAT3, XDH
BP	GO:0065007; biological regulation	GO:0051345; positive regulation of hydrolase activity	5.578E-05	1.735E-01	PTPN1, STAT3, XDH
BP	GO:0008152; metabolic process	GO:2000377; regulation of reactive oxygen species metabolic process	2.270E-04	1.789E-01	STAT3, XDH
BP	GO:0008152; metabolic process	GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation	2.379E-04	1.789E-01	PTPN1, STAT3
CC	GO:0044464; cell part	GO:0097443; sorting endosome	9.316E-04	2.940E-01	PTPN1
CC	GO:0044464; cell part	GO:0005829; cytosol	1.571E-02	1.000E+00	PTPN1, STAT3, XDH
CC	GO:0032991; macromolecular complex	GO:0090575; RNA polymerase II transcription factor complex	2.021E-02	1.000E+00	STAT3
MF	GO:0005488; binding	GO:0019903; protein phosphatase binding	1.106E-04	1.789E-01	PTPN1, STAT3
MF	GO:0005488; binding	GO:0043546; molybdopterin cofactor binding	9.316E-04	2.940E-01	XDH

Showing 1 to 10 of 10 entries

Previous1Next

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	7.498E-04	1.050E-02	XDH
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	1.982E-02	3.204E-02	STAT3
09140 Cellular Processes	09141 Transport and catabolism	hsa04146	Peroxisome	1.240E-02	3.204E-02	XDH
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	1.046E-02	3.204E-02	STAT3
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	8.798E-05	2.463E-03	PTPN1, STAT3
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.507E-02	3.204E-02	STAT3
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	1.760E-02	3.204E-02	STAT3
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.982E-02	3.204E-02	STAT3
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	2.026E-02	3.204E-02	STAT3
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	2.174E-02	3.204E-02	STAT3

Showing 1 to 10 of 10 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	STAT3;
C00-D49: Neoplasms	Cancer	C00-C96	STAT3;
C00-D49: Neoplasms	Solid tumours	C00-D48	STAT3;
C00-D49: Neoplasms	Multiple myeloma	C90	STAT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	STAT3;

Showing 1 to 5 of 5 entries

Previous1Next

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Synotis alata

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities