CMAUP Plant Collective Molecular Activities

Plant Name: Trichosanthes kirilowii maxim

Taxonomic Information:

Plant ID: NPO16497
Plant Latin Name: Trichosanthes kirilowii maxim
Taxonomy Genus: Trichosanthes
Taxonomy Family: Cucurbitaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family C GPCR)	GRM8; GRM1;
Small molecule receptor (family A GPCR)	ADORA3;
Ionotropic glutamate receptor	GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Enzyme_unclassified	ALOX15;
Transcription Factor	NFKB1;
SLC superfamily of solute carriers	SLC1A1;
Unclassified	FABP4; LMNA; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Ionotropic glutamate receptor	GRIA4	Glutamate receptor ionotropic, AMPA 4	P48058	CHEMBL3190
Ionotropic glutamate receptor	GRIA2	Glutamate receptor ionotropic, AMPA 2	P42262	CHEMBL4016
Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
SLC superfamily of solute carriers	SLC1A1	Excitatory amino acid transporter 3	P43005	CHEMBL2721
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family C GPCR)	GRM8	Metabotropic glutamate receptor 8	O00222	CHEMBL3228
Small molecule receptor (family C GPCR)	GRM1	Metabotropic glutamate receptor 1	Q13255	CHEMBL3772
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005215; transporter activity	GO:0005234; extracellularly glutamate-gated ion channel activity	4.414E-12	2.403E-08	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	2.487E-11	1.083E-07	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	4.148E-09	7.526E-06	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0015277; kainate selective glutamate receptor activity	6.787E-09	1.054E-05	GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0007196; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	5.687E-08	7.285E-05	GRIK3, GRM1, GRM8
BP	GO:0023052; signaling	GO:0051966; regulation of synaptic transmission, glutamatergic	2.326E-07	2.533E-04	GRIK1, GRIK3, GRM1, GRM8
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.189E-06	1.083E-03	CYP1A1, CYP1B1, CYP3A4
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	1.132E-06	1.083E-03	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	2.459E-06	1.847E-03	CYP1A1, CYP3A4
MF	Unclassified;	GO:0004872; receptor activity	3.455E-06	2.508E-03	ADORA3, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, GRM1, GRM8, PPARA
MF	GO:0005215; transporter activity	GO:0004971; AMPA glutamate receptor activity	4.916E-06	3.345E-03	GRIA2, GRIA4
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	8.188E-06	4.052E-03	CYP1A1, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	9.408E-06	4.454E-03	CYP1A1, CYP1B1, CYP3A4
CC	GO:0044425; membrane part	GO:0008328; ionotropic glutamate receptor complex	1.006E-05	4.571E-03	GRIA2, GRIA4, GRIK5
MF	GO:0005215; transporter activity	GO:0008381; mechanosensitive ion channel activity	1.053E-05	4.585E-03	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.228E-05	5.043E-03	CYP1A1, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.267E-05	5.111E-03	ALOX15, CYP1A1, CYP1B1, CYP3A4
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	1.971E-05	7.401E-03	ADORA3, ALOX15, CYP1A1, PPARA
CC	GO:0044456; synapse part	GO:0042734; presynaptic membrane	2.483E-05	9.011E-03	GRIK5, GRM1, GRM8

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	3.623E-14	3.224E-12	GRIA2, GRIK5, SLC1A1, GRM8, GRIK3, GRIK1, GRM1, GRIA4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4.750E-11	2.114E-09	GRIA2, GRIK5, ADORA3, GRM8, GRIK3, GRIK1, GRM1, GRIA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.609E-05	5.429E-04	GRIA2, PPARA, NFKB1, GRIA4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.831E-05	5.429E-04	CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.660E-05	5.429E-04	CYP1A1, CYP1B1, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.090E-05	5.429E-04	FABP4, FABP5, PPARA
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	9.653E-05	1.074E-03	GRIA2, GRM1, GRIA4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.185E-05	6.592E-04	CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.848E-04	4.731E-03	CYP1A1, CYP1B1
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	5.848E-04	4.731E-03	GRIA2, GRIA4
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	9.135E-04	6.254E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.062E-04	3.028E-03	ALOX15, CYP3A4
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	8.774E-04	6.254E-03	GRIA2, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	1.313E-03	8.346E-03	GRIA2, GRM1
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	1.634E-03	8.554E-03	GRIA2, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	1.586E-03	8.554E-03	GRIA2, GRM1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.539E-03	8.554E-03	CYP1A1, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	1.782E-03	8.810E-03	PPARA, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	GRM1; GRIK1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	GRM1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	GRIK1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	GRM1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	GRM1; GRIK1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	GRM1;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	GRIA2; GRIA4;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	GRM1; GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	GRIK1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases